Acetaminophen (APAP)-induced acute hepatotoxicity is the leading cause of drug-induced
acute liver failure. The aim of this study was to evaluate the effects of 4-hydroxy-2, 2, 6, 6 …

An overdose of acetaminophen (APAP), the most common cause of acute liver injury,
induces oxidative stress that subsequently causes mitochondrial impairment and hepatic …

Acute liver injury is a debilitating disorder associated with loss of synthetic and detoxifying
functions of the liver. This investigation was designed to assess cytoprotective efficacy of …

We previously reported that delayed treatment with Mito-tempo (MT), a mitochondria-
targeted superoxide dismutase mimetic, protects against the early phase of acetaminophen …

Ethnopharmacological relevance Oroxyloside is a natural flavonoid isolated from Scutellaria
baicalensis Georgi (Lamiaceae) which is a Chinese herb widely used for liver diseases …

Background/Aims: Pterostilbene (Pts), a natural dimethylated analog of resveratrol from
blueberries, exerts antioxidative and anti-apoptotic effects in various diseases. This study …

The aim of the study was to investigate the ameliorative effects and the mechanism of action
of l-2-oxothiazolidine-4-carboxylate (OTC) on acetaminophen (APAP)-induced …

Acetaminophen (APAP) is a common antipyretic and analgesic drug, but its overdose can
induce acute liver failure with lack of effective therapies. Hesperetin, a dihydrogen flavonoid …

Acetaminophen (APAP) overdose is one of the major causes of acute liver failure. Severe
liver inflammation and the production of oxidative stress occur due to toxic APAP metabolites …

The present study aimed to investigate the effect of simvastatin on acetaminophen (APAP)
hepatotoxicity in a mouse model. Male C57BL/6 mice were allocated into the following …