The prevalence of type 2 diabetes mellitus (T2DM) has been increasing worldwide.
Therefore, a novel therapeutic strategy by which to prevent T2DM is urgently required …

The rising incidence of type 2 diabetes mellitus (T2DM) is a major public health problem in
industrialized countries, and new therapeutic strategies to prevent T2DM are urgently …

Insulin resistance is often characterized as the most critical factor contributing to the
development of type 2 diabetes. SIRT1 has been reported to be involved in the processes of …

The rising incidence of type 2 diabetes mellitus (T2DM) is a major public health concern,
and novel therapeutic strategies to prevent T2DM are urgently needed worldwide. Aging is …

Abstract Sirtuin 1 (S IRT1), the mammalian homolog of SIR2, was originally identified as a
NAD-dependent histone deacetylase, the activity of which is closely associated with lifespan …

Abstract Sirtuin 1 (SIRT1) is a prototype mammalian NAD (+)-dependent protein deacetylase
that has emerged as a key metabolic sensor in various metabolic tissues. Growing evidence …

Dysregulation of metabolic pathways leads to type 2 diabetes, characteristic of high glucose
concentration caused by insulin resistance. The histone deacetylases sirtuins exhibit …

Abstract Sirtuin 6 (SIRT6) is a sirtuin family member involved in a wide range of physiologic
and disease processes, including cancer and glucose homeostasis. Based on the roles …

Abstract Sirtuin 1 (SIRT1) is the most conserved mammalian NAD+-dependent protein
deacetylase that has emerged as a key metabolic sensor in various metabolic tissues. In …

Sirt6 is one of the sirtuin family members, a kind of NAD+-dependent histone deacetylase
and ADP-ribose transferase enzyme. It has an important role in physiological and …