Heart failure is a condition whereby the weakened cardiac muscle can no longer pump
blood to the rest of the body, resulting in decreased quality of life. Despite the severity of this …

Aims The failing heart is energy-starved and inefficient due to perturbations in energy
metabolism. Although ketone oxidation has been shown recently to increase in the failing …

The high energy demands of the heart are met primarily by the mitochondrial oxidation of
fatty acids and glucose. However, in heart failure there is a decrease in cardiac …

Heart failure is a systemic disease in which both myocardium and skeletal muscle exhibit
alterations of energy metabolism. Failing myocardium exhibits impaired utilization of free …

Ketone bodies can become a major source of adenosine triphosphate production during
stress to maintain bioenergetic homeostasis in the brain, heart, and skeletal muscles. In the …

Objective Exploitation of protective metabolic pathways within injured myocardium still
remains an unclarified therapeutic target in heart disease. Moreover, while the roles of …

During conditions that result in depleted circulating glucose levels, ketone bodies
synthesized in the liver are necessary fuel substrates for the brain. In other organs, such as …

Heart failure is of major clinical and economic importance and remains a major public health
problem worldwide. Despite existing treatment approaches, morbidity and mortality in these …

Aims Cardiac energy metabolism is perturbed in ischaemic heart failure and is characterized
by a shift from mitochondrial oxidative metabolism to glycolysis. Notably, the failing heart …

Despite existing therapy, patients with heart failure (HF) experience substantial morbidity
and mortality, highlighting the urgent need to identify novel pathophysiological mechanisms …