Recent studies have found that those who suffer from posttraumatic stress disorder (PTSD)
are more likely to experience dementia as they age, most often Alzheimer's disease (AD) …

Stress is a major risk factor for depression and anxiety. One of the effects of stress is the
(over-) activation of the hypothalamic-pituitary-adrenal (HPA) axis and the release of stress …

Neuroinflammation, which is mediated by microglia, astrocytes, and infiltrated immune cells
and leads to the subsequent production of proinflammatory molecules, is associated with the …

Abstract Alzheimer's disease (AD), a prevalent form of dementia, is characterized by the
decline of cognitive abilities with age. Available treatment options for AD are limited, making …

The 3xTg‐AD mouse develops a progressive Alzheimer′ s disease‐(AD‐) like brain
pathology that causes cognitive‐and neuropsychiatric‐like symptoms of dementia. Since its …

The Glucocorticoid Receptor (GR) is a transcription factor ubiquitously expressed in the
brain. Activation of brain GRs by high levels of glucocorticoid (GC) hormones modifies a …

BACKGROUND: Heightened stress reactivity is associated with hippocampal atrophy, age-
related cognitive deficits, and increased risk for Alzheimer's disease. This temperament …

Differences in brain function are a central determinant of individual variability in the stress
response. Brain dysfunction, resulting from aging, illness, or genetic mutations, could reduce …

Reactivity to environmental stressors influences vulnerability to neurological and psychiatric
illnesses, but little is known about molecular mechanisms that control this reactivity. Since …

Background The risk of developing Alzheimer's disease (AD) is modulated by genetic and
environmental factors. Early-life stress (ELS) exposure during critical periods of brain …