Chronic stress contributes to numerous human pathologies including cognition impairments
and psychiatric disorders. Glucocorticoids are primary stress hormones that activate two …

The developing fetus is highly sensitive to prenatal stress, which may alter Hypothalamic-
Pituitary-Adrenal (HPA) axis programming and increase the risk of behavioral disorders …

Introduction Epidemiological studies show that women have a higher prevalence of
Alzheimer's disease (AD) than men. Peripheral estrogen reduction during aging in women is …

Clinical studies have shown that female brains are more predisposed to neurodegenerative
diseases such as Alzheimer's disease (AD), but the cellular and molecular mechanisms …

Chronic exposure to stress during midlife associates with subsequent age-related cognitive
decline and may increase the vulnerability to develop psychiatric conditions. Increased …

Susceptibility and resilience to stress depend on 1) the timing of the exposure with respect to
development, 2) the time across the life span at which effects are measured, and 3) the …

Healthy aging individuals are more likely to suffer profound memory impairments following
an immune challenge than are younger adults. These challenges produce a brain …

Depletion of estrogens and progesterone at menopause has been linked to an increased
risk for the development of Alzheimer's disease (AD) in women. A currently controversial …

Women carry a higher burden of Alzheimer's disease (AD) compared to men, which is not
accounted entirely by differences in lifespan. To identify the mechanisms underlying this …

Men and women differ in their vulnerability to a variety of stress-related illnesses, but the
underlying neurobiological mechanisms are not well understood. This is likely due to a …