Interspecies communication among commensal and pathogenic streptococci

LC Cook, B LaSarre, MJ Federle - MBio, 2013 - Am Soc Microbiol
Quorum sensing (QS) regulates diverse and coordinated behaviors in bacteria, including the
production of virulence factors, biofilm formation, sporulation, and competence development …

Redundant group a streptococcus signaling peptides exhibit unique activation potentials

B LaSarre, JC Chang, MJ Federle - Journal of bacteriology, 2013 - Am Soc Microbiol
All bacterial quorum sensing (QS) systems are based on the production, secretion, and
detection of small signaling molecules. Gram-positive bacteria typically use small peptides …

A quorum sensing-regulated protein binds cell wall components and enhances lysozyme resistance in Streptococcus pyogenes

A Gogos, JC Jimenez, JC Chang… - Journal of …, 2018 - Am Soc Microbiol
ABSTRACT The Rgg2/3 quorum sensing (QS) system is conserved among all sequenced
isolates of group A Streptococcus (GAS; Streptococcus pyogenes). The molecular …

Antagonistic Rgg regulators mediate quorum sensing via competitive DNA binding in Streptococcus pyogenes

B LaSarre, C Aggarwal, MJ Federle - MBio, 2012 - Am Soc Microbiol
Recent studies have established the fact that multiple members of the Rgg family of
transcriptional regulators serve as key components of quorum sensing (QS) pathways that …

Identification of quorum-sensing inhibitors disrupting signaling between Rgg and short hydrophobic peptides in streptococci

C Aggarwal, JC Jimenez, H Lee, GE Chlipala, K Ratia… - MBio, 2015 - Am Soc Microbiol
Bacteria coordinate a variety of social behaviors, important for both environmental and
pathogenic bacteria, through a process of intercellular chemical signaling known as quorum …

[HTML][HTML] Quorum sensing in group A Streptococcus

JC Jimenez, MJ Federle - Frontiers in cellular and infection …, 2014 - frontiersin.org
Quorum sensing (QS) is a widespread phenomenon in the microbial world that has
important implications in the coordination of population-wide responses in several bacterial …

[HTML][HTML] Identification of a Quorum Sensing System Regulating Capsule Polysaccharide Production and Biofilm Formation in Streptococcus zooepidemicus

Z Xie, K Meng, X Yang, J Liu, J Yu, C Zheng… - Frontiers in Cellular …, 2019 - frontiersin.org
Streptococcus zooepidemicus is an important opportunistic pathogen of several species
including humans. This organism is also well-known as the main producing strain in …

[HTML][HTML] Rgg-associated SHP signaling peptides mediate cross-talk in Streptococci

B Fleuchot, A Guillot, C Mezange, C Besset… - PLoS …, 2013 - journals.plos.org
We described a quorum-sensing mechanism in the streptococci genus involving a short
hydrophobic peptide (SHP), which acts as a pheromone, and a transcriptional regulator …

A Streptococcus Quorum Sensing System Enables Suppression of Innate Immunity

KM Rahbari, JC Chang, MJ Federle - MBio, 2021 - Am Soc Microbiol
Some bacterial pathogens utilize cell-cell communication systems, such as quorum sensing
(QS), to coordinate genetic programs during host colonization and infection. The human …

Structure–function studies of Rgg binding to pheromones and target promoters reveal a model of transcription factor interplay

GC Capodagli, KM Tylor, JT Kaelber… - Proceedings of the …, 2020 - National Acad Sciences
Regulator gene of glucosyltransferase (Rgg) family proteins, such as Rgg2 and Rgg3, have
emerged as primary quorum-sensing regulated transcription factors in Streptococcus …