[HTML][HTML] A systematic review on maternal-to-infant transfer of drugs through breast milk during the treatment of malaria, tuberculosis, and neglected tropical diseases

FW Ojara, AN Kawuma, C Waitt - PLOS Neglected Tropical …, 2023 - journals.plos.org
Background Exclusive breastfeeding of infants under 6 months of age is recommended by
the World Health Organization. In 2021, over 300 million combined incident cases of …

[HTML][HTML] Pharmacokinetics of antimalarial drugs used to treat uncomplicated malaria in breastfeeding mother-infant pairs: An observational pharmacokinetic study

R Nakijoba, AN Kawuma, FW Ojara… - Wellcome open …, 2023 - ncbi.nlm.nih.gov
Background: Data surrounding the exposure of the breastfed infant to drugs and any
associated risks are sparse. Drugs usually are transferred to milk in small quantities, and …

Is infant exposure to antiretroviral drugs during breastfeeding quantitatively important? A systematic review and meta-analysis of pharmacokinetic studies

CJ Waitt, P Garner, LJ Bonnett… - Journal of …, 2015 - academic.oup.com
Objectives The objectives of this study were to summarize antiretroviral drug concentrations
in breast milk (BM) and exposure of breast-fed infants. Methods This was a systematic …

[HTML][HTML] Pharmacokinetics of drugs used to treat drug sensitive-tuberculosis in breastfeeding mother-infant pairs: An observational pharmacokinetic study

R Nakijoba, AN Kawuma, FW Ojara… - Wellcome Open …, 2024 - wellcomeopenresearch.org
Background Globally, more than half of women take medicines whilst breastfeeding. Data
concerning the exposure of the breastfed infant to drugs and any related risks are sparce …

[HTML][HTML] A comprehensive review on non-clinical methods to study transfer of medication into breast milk–A contribution from the ConcePTION project

N Nauwelaerts, N Deferm, A Smits, C Bernardini… - Biomedicine & …, 2021 - Elsevier
Breastfeeding plays a major role in the health and wellbeing of mother and infant. However,
information on the safety of maternal medication during breastfeeding is lacking for most …

[HTML][HTML] Determining the exposure of maternal medicines through breastfeeding: the UmbrelLACT study protocol—a contribution from the ConcePTION project

M Van Neste, N Nauwelaerts, M Ceulemans… - BMJ Paediatrics …, 2024 - ncbi.nlm.nih.gov
Introduction Breastfeeding is beneficial for the health of the mother and child. However, at
least 50% of postpartum women need pharmacotherapy, and this number is rising due to the …

Emerging research paradigm for infant drug exposure through breast milk

S Ito - Current Pharmaceutical Design, 2019 - ingentaconnect.com
Background: Information on drug secretion into milk is insufficient due to the exclusion of
lactating women from clinical trials and drug development processes. As a result, non …

Determinants of drug transfer into human milk

EJ Begg - Drugs and human lactation, 1996 - Elsevier
Publisher Summary This chapter discusses three major components that affect drug transfer
into human milk and the suckling infant, including maternal pharmacokinetics, mammary …

Safety of medicines during breastfeeding–from case report to modeling: a contribution from the ConcePTION project

E Cardoso, M Guidi, N Nauwelaerts… - Expert opinion on …, 2023 - Taylor & Francis
Introduction Despite many research efforts, current data on the safety of medicines during
breastfeeding are either fragmented or lacking, resulting in restrictive labeling of most …

Non-clinical models to determine drug passage into human breast milk

D Ventrella, M Forni, ML Bacci… - Current Pharmaceutical …, 2019 - ingentaconnect.com
Background: Successful practice of clinical perinatal pharmacology requires a thorough
understanding of the pronounced physiological changes during lactation and how these …