Recent studies using known Rho-associated kinase isoform 1 (ROCK1) inhibitors along with
cellular and molecular biology data have revealed a pivotal role of this enzyme in many …

Rho kinase (ROCK1) mediates vascular smooth muscle contraction and is a potential target
for the treatment of hypertension and related disorders. Indazole amide 3 was identified as a …

Rho kinase (ROCK) belongs to a family of Ser/Thr protein kinases that are activated via
interaction with the small GTP-binding protein RhoA. Growing evidence suggests that RhoA …

Rho-kinase (ROCK) is one of the downstream effectors of the small G-protein Rho. The Rho–
ROCK pathway has an important role in mediating various cellular functions, including …

RhoA and Rho-kinase (ROCK) participate in diverse cellular signaling functions such as
smooth muscle contraction, cytoskeleton rearrangement, and cell migration and …

The Rho kinase (ROCK) isoforms, ROCK1 and ROCK2, were initially discovered as
downstream targets of the small GTP-binding protein Rho. Because ROCKs mediate various …

Phenylglycine substituted isoquinolones 1 and 2 have previously been described as potent
dual ROCK1/ROCK2 inhibitors. Here we describe the further SAR of this series to improve …

ABSTRACT Introduction: The Rho-kinases (ROCK), ROCK1 and ROCK2, are potent,
widespread biochemical modulators which have been extensively studied. Due to the …

Rho kinase is an important target implicated in a variety of cardiovascular diseases. Herein,
we report the optimisation of the fragment derived ATP-competitive ROCK inhibitors 1 and 2 …

The Rho kinases (ROCK1 and ROCK2) are highly homologous serine/threonine kinases
that act on substrates associated with cellular motility, morphology, and contraction and are …