The proportion of pregnant women who are obese at conception continues to rise.
Compelling evidence suggests the intrauterine environment is an important determinant of …

Aim The current study investigated the impact of maternal obesity on placental phenotype in
relation to fetal growth and sex. Methods Female C57BL6/J mice were fed either a diet high …

Maternal obesity impairs offspring health, but the responsible mechanisms are not fully
established. To address this question, we fed female mice a high-fat/high-sugar diet from …

The negative impact of obesity on reproductive success is well documented but the stages at
which development of the conceptus is compromised and the mechanisms responsible for …

Low birth weight is associated with an increased risk for developing type 2 diabetes and
metabolic diseases. The placental capacity to supply nutrients and oxygen to the fetus …

In vivo and in vitro studies demonstrate that mitochondria in the oocyte, are susceptible to
damage by suboptimal pre/pregnancy conditions, such as obesity. These suboptimal …

In utero exposure to maternal obesity increases the offspring's risk of obesity in later life. We
have also previously reported that offspring of obese rat dams develop hepatic steatosis …

The placenta plays a key role in regulation of fetal growth and development and in
mediating in utero developmental programming. Obesity, which is associated with chronic …

Background Effective fetal growth requires adequate maternal nutrition coupled to active
transport of nutrients across the placenta, which, in turn requires ATP. Epidemiological and …

Uteroplacental insufficiency has been shown to impair insulin action and glucose
homeostasis in adult offspring and may act in part via altered mitochondrial biogenesis and …