In utero exposure to prepregnancy maternal obesity and postweaning high-fat diet impair regulators of mitochondrial dynamics in rat placenta and offspring
SJ Borengasser, J Faske, P Kang… - Physiological …, 2014 - journals.physiology.org
The proportion of pregnant women who are obese at conception continues to rise.
Compelling evidence suggests the intrauterine environment is an important determinant of …
Compelling evidence suggests the intrauterine environment is an important determinant of …
Diet‐induced maternal obesity impacts feto‐placental growth and induces sex‐specific alterations in placental morphology, mitochondrial bioenergetics, dynamics …
T Napso, SC Lean, M Lu, EJ Mort… - Acta …, 2022 - Wiley Online Library
Aim The current study investigated the impact of maternal obesity on placental phenotype in
relation to fetal growth and sex. Methods Female C57BL6/J mice were fed either a diet high …
relation to fetal growth and sex. Methods Female C57BL6/J mice were fed either a diet high …
Maternal metabolic syndrome programs mitochondrial dysfunction via germline changes across three generations
JL Saben, AL Boudoures, Z Asghar, A Thompson… - Cell reports, 2016 - cell.com
Maternal obesity impairs offspring health, but the responsible mechanisms are not fully
established. To address this question, we fed female mice a high-fat/high-sugar diet from …
established. To address this question, we fed female mice a high-fat/high-sugar diet from …
Maternal diet-induced obesity alters mitochondrial activity and redox status in mouse oocytes and zygotes
The negative impact of obesity on reproductive success is well documented but the stages at
which development of the conceptus is compromised and the mechanisms responsible for …
which development of the conceptus is compromised and the mechanisms responsible for …
Maternal calorie restriction modulates placental mitochondrial biogenesis and bioenergetic efficiency: putative involvement in fetoplacental growth defects in rats
S Mayeur, S Lancel, N Theys… - American Journal …, 2013 - journals.physiology.org
Low birth weight is associated with an increased risk for developing type 2 diabetes and
metabolic diseases. The placental capacity to supply nutrients and oxygen to the fetus …
metabolic diseases. The placental capacity to supply nutrients and oxygen to the fetus …
[HTML][HTML] Mitochondrial dysfunction in the offspring of obese mothers and it's transmission through damaged oocyte mitochondria: Integration of mechanisms
AL Elias-Lopez, O Vázquez-Mena… - Biochimica et Biophysica …, 2023 - Elsevier
In vivo and in vitro studies demonstrate that mitochondria in the oocyte, are susceptible to
damage by suboptimal pre/pregnancy conditions, such as obesity. These suboptimal …
damage by suboptimal pre/pregnancy conditions, such as obesity. These suboptimal …
Maternal obesity during gestation impairs fatty acid oxidation and mitochondrial SIRT3 expression in rat offspring at weaning
SJ Borengasser, F Lau, P Kang, ML Blackburn… - PloS one, 2011 - journals.plos.org
In utero exposure to maternal obesity increases the offspring's risk of obesity in later life. We
have also previously reported that offspring of obese rat dams develop hepatic steatosis …
have also previously reported that offspring of obese rat dams develop hepatic steatosis …
Impaired mitochondrial function in human placenta with increased maternal adiposity
J Mele, S Muralimanoharan… - American Journal of …, 2014 - journals.physiology.org
The placenta plays a key role in regulation of fetal growth and development and in
mediating in utero developmental programming. Obesity, which is associated with chronic …
mediating in utero developmental programming. Obesity, which is associated with chronic …
Is placental mitochondrial function a regulator that matches fetal and placental growth to maternal nutrient intake in the mouse?
MR Chiaratti, S Malik, A Diot, E Rapa, L Macleod… - PloS one, 2015 - journals.plos.org
Background Effective fetal growth requires adequate maternal nutrition coupled to active
transport of nutrients across the placenta, which, in turn requires ATP. Epidemiological and …
transport of nutrients across the placenta, which, in turn requires ATP. Epidemiological and …
Uteroplacental insufficiency and reducing litter size alters skeletal muscle mitochondrial biogenesis in a sex-specific manner in the adult rat
Uteroplacental insufficiency has been shown to impair insulin action and glucose
homeostasis in adult offspring and may act in part via altered mitochondrial biogenesis and …
homeostasis in adult offspring and may act in part via altered mitochondrial biogenesis and …