The coming together of allosteric and phosphorylation mechanisms in the molecular integration of A2A heteroreceptor complexes in the dorsal and ventral striatal …

DO Borroto-Escuela, L Ferraro, S Beggiato… - Pharmacological …, 2021 - Springer
The role of adenosine A2A receptor (A2AR) and striatal-enriched protein tyrosine
phosphatase (STEP) interactions in the striatal-pallidal GABA neurons was recently …

Receptor heteromerization in adenosine A2A receptor signaling: Relevance for striatal function and Parkinson's disease

K Fuxe, LF Agnati, K Jacobsen, J Hillion, M Canals… - Neurology, 2003 - AAN Enterprises
Recently evidence has been presented that adenosine A2A and dopamine D2 receptors
form functional heteromeric receptor complexes as demonstrated in human neuroblastoma …

Adenosine A2A-D2 receptor-receptor interactions in putative heteromers in the regulation of the striato-pallidal gaba pathway: possible relevance for parkinson's …

S Beggiato, T Antonelli, MC Tomasini… - Current Protein and …, 2014 - ingentaconnect.com
Striatal dopamine adenosine A2A and D2 receptors interact to modulate some aspects of
motor and motivational function. The demonstration of A2A/D2 receptor heteromerization in …

Adenosine A2A Receptors in Striatal Glutamatergic Terminals and GABAergic Neurons Oppositely Modulate Psychostimulant Action and DARPP-32 Phosphorylation

HY Shen, PM Canas, P Garcia-Sanz, JQ Lan… - PLoS …, 2013 - journals.plos.org
Adenosine A2A receptors (A2AR) are located postsynaptically in striatopallidal GABAergic
neurons, antagonizing dopamine D2 receptor functions, and are also located …

[HTML][HTML] Adenosine A2A Receptors and A2A Receptor Heteromers as Key Players in Striatal Function

S Ferré, C Quiroz, M Orru, X Guitart… - Frontiers in …, 2011 - frontiersin.org
A very significant density of adenosine A2A receptors (A2ARs) is present in the striatum,
where they are preferentially localized postsynaptically in striatopallidal medium spiny …

Adenosine A2A receptors and basal ganglia physiology

SN Schiffmann, G Fisone, R Moresco, RA Cunha… - Progress in …, 2007 - Elsevier
Adenosine A2A receptors are highly enriched in the basal ganglia system. They are
predominantly expressed in enkephalin-expressing GABAergic striatopallidal neurons and …

Adenosine STEPs on synaptic function: An Editorial for 'The activity of the STriatal‐enriched protein tyrosine phosphatase in neuronal cells is modulated by adenosine …

RP Yasuda - Journal of Neurochemistry, 2020 - Wiley Online Library
Abstract This is an Editorial Highlight of a manuscript by Mallozzi et al.(2019) in the current
issue of the Journal of Neurochemistry, in which the authors detail the biochemical pathway …

A2A/D2 receptor heteromerization in a model of Parkinson's disease. Focus on striatal aminoacidergic signaling

L Ferraro, S Beggiato, MC Tomasini, K Fuxe… - Brain research, 2012 - Elsevier
The present manuscript mainly summarizes the basic concepts and the molecular
mechanisms underlying adenosine A2A-dopamine D2 receptor–receptor interactions in the …

Functional role of striatal A2A, D2, and mG lu5 receptor interactions in regulating striatopallidal GABA neuronal transmission

S Beggiato, MC Tomasini, AC Borelli… - Journal of …, 2016 - Wiley Online Library
In this study, the functional role of individual striatal receptors for adenosine (A2 AR),
dopamine (D2R), and the metabotropic glutamate receptor mG lu5R in regulating rat basal …

Key Modulatory Role of Presynaptic Adenosine A2A Receptors in Cortical Neurotransmission to the Striatal Direct Pathway

C Quiroz, R Luján, M Uchigashima… - The Scientific World …, 2009 - hindawi.com
Basal ganglia processing results from a balanced activation of direct and indirect striatal
efferent pathways, which are controlled by dopamine D 1 and D 2 receptors, respectively …