Objective Randomized controlled trials (RCT s) exist along a spectrum, from explanatory,
designed to evaluate interventions under ideal conditions, to pragmatic, designed to reflect …

Objective. The aim of this study was to explore which clinical factors and patient
characteristics are associated with the magnitude of comparative efficacy between biologics …

Objective: To evaluate the efficacy and toxicity of methotrexate (MTX) monotherapy
compared with MTX combination with non-biological disease-modifying antirheumatic drugs …

Background Methotrexate (MTX) is among the most effective disease modifying anti‐
rheumatic drugs (DMARDs) in rheumatoid arthritis (RA) with less toxicity and better …

Objectives To evaluate if optimal dose of either oral or injectable regimens of methotrexate
(MTX) of 25 mg/week was used in the comparator arms of studies comparing biologic drugs …

Study Objective. To compare the efficacy of biologic disease‐modifying antirheumatic drugs
(DMARDs) versus placebo with or without methotrexate, in treating rheumatoid arthritis …

Objective Pragmatic clinical trials have been proposed as a solution for nongeneralizability
of randomized clinical trial (RCT) results. We investigated whether treatment effects of …

Objectives To assess the efficacy and safety of methotrexate (MTX) in combination with an
approved biological agent compared to biological monotherapy, in the management of …

Background Methotrexate (MTX) is considered the anchor drug in rheumatoid arthritis (RA)
treatment, both on the basis of its efficacy and safety as monotherapy, as well as its ability to …

Study design Inclusion/exclusion criteria Baseline disease activity (clinical, functional, x-ray)
Baseline indices of disease activity (laboratory) Disease duration Length of study …