Sesamol, a major lignan in sesame seeds (Sesamum indicum): Anti-cancer properties and mechanisms of action

AF Majdalawieh, ZR Mansour - European journal of pharmacology, 2019 - Elsevier
Sesamol is a natural phenolic compound and a major lignan isolated from sesame seeds
(Sesamum indicum) and sesame oil. The therapeutic potential of sesamol was investigated …

A comprehensive review on the anti-cancer properties and mechanisms of action of sesamin, a lignan in sesame seeds (Sesamum indicum)

AF Majdalawieh, M Massri, GK Nasrallah - European journal of …, 2017 - Elsevier
Sesamin is the major active ingredient is Sesamum indicum seeds. Several studies revealed
that sesamin possesses potent anti-cancer properties. The anti-cancer effects of sesamin …

[HTML][HTML] An insight into sesamolin: physicochemical properties, pharmacological activities, and future research prospects

R Rosalina, N Weerapreeyakul - Molecules, 2021 - mdpi.com
Sesame seeds are rich in lignan content and have been well-known for their health benefits.
Unlike the other sesame lignan compounds (ie, sesamin and sesamol), the study of the …

Sesame (Sesamum indicum L.) seeds in food, nutrition, and health

M Elleuch, D Bedigian, A Zitoun - Nuts and seeds in health and disease …, 2011 - Elsevier
Publisher Summary This chapter outlines the nutritional and health benefits of sesame
seeds. Sesame seeds have been used as a health food for disease prevention in Asian …

[HTML][HTML] Sesamin inhibits lipopolysaccharide-induced proliferation and invasion through the p38-MAPK and NF-κB signaling pathways in prostate cancer cells

P Xu, F Cai, X Liu, L Guo - Oncology reports, 2015 - spandidos-publications.com
Sesamin, a lipid-soluble lignan, is one of the major constituents of sesame. Previous studies
have reported that sesamin induces growth inhibition in human cancer cells, particularly …

Immunomodulatory and anti-inflammatory effects of sesamin: mechanisms of action and future directions

AF Majdalawieh, SM Yousef… - Critical reviews in …, 2022 - Taylor & Francis
Inflammation is associated with the development and progression of various disorders
including atherosclerosis, diabetes mellitus and cancer. Sesamin, a fat-soluble lignan …

Sesamin manifests chemopreventive effects through the suppression of NF-κB–regulated cell survival, proliferation, invasion, and angiogenic gene products

KB Harikumar, B Sung, ST Tharakan, MK Pandey… - Molecular Cancer …, 2010 - AACR
Agents that are safe, affordable, and efficacious are urgently needed for the prevention of
chronic diseases such as cancer. Sesamin, a lipid-soluble lignan, is one such agent that …

[HTML][HTML] Sesamol induces human hepatocellular carcinoma cells apoptosis by impairing mitochondrial function and suppressing autophagy

Z Liu, B Ren, Y Wang, C Zou, Q Qiao, Z Diao, Y Mi… - Scientific Reports, 2017 - nature.com
Sesamol, a nutritional phenolic antioxidant compound enriched in sesame seeds, has been
shown to have potential anticancer activities. This study aims at characterizing the antitumor …

Sesamin, a lignan of sesame, down‐regulates cyclin D1 protein expression in human tumor cells

T Yokota, Y Matsuzaki, M Koyama, T Hitomi… - Cancer …, 2007 - Wiley Online Library
Sesamin is a major lignan constituent of sesame and possesses multiple functions such as
antihypertensive, cholesterol‐lowering, lipid‐lowering and anticancer activities. Several …

Antioxidative roles of sesamin, a functional lignan in sesame seed, and it's effect on lipid‐and alcohol‐metabolism in the liver: A DNA microarray study

Y Kiso - Biofactors, 2004 - Wiley Online Library
Sesamin was orally administered to rats, and blood, bile and urine were collected
periodically. Over 40% of the dose of sesamin was detected in bile as glucuronides of 2‐(3 …