Epigenetic modifiers (EM; methionine, choline, folate, and vitamin B12) are important for
early embryonic development due to their roles as methyl donors or cofactors in methylation …

In many cell types, epigenetic changes are partially regulated by the availability of
metabolites involved in the activity of chromatin-modifying enzymes. Even so, the …

The methylation pathway, which consists of two metabolic cycles of nutrients, ie, the
methionine and folate cycles, generates S‐adenosylmethionine, the methyl donor for the …

Aim: There is a growing concern about the potential adverse effects of high dose folic acid
(FA) supplementation before and during pregnancy. FA metabolism generates S-adenosyl …

Abstract Background Mitochondrial DNA (mtDNA) copy number in oocytes correlates with
oocyte quality and fertilisation outcome. The introduction of additional copies of mtDNA …

Supplementation of micronutrients involved in DNA methylation, particularly during
pregnancy, is recommended because of its impacts on human health, but further evidence is …

The preimplantation period of embryonic development can be a key window for
programming of postnatal development because extensive epigenetic remodeling occurs …

Aberrant epigenetic reprogramming is known to be a major cause of inefficient somatic cell
nuclear transfer (SCNT) in pigs, and use of epigenetic modification agents, such as DNA …

One-carbon (1C) metabolism provides methyl groups for the synthesis and/or methylation of
purines and pyrimidines, biogenic amines, proteins, and phospholipids. Our understanding …

Background Embryonic and fetal development is very susceptible to the availability of
nutrients that can interfere with the setting of epigenomes, thus modifying the main metabolic …