Systematic efforts are underway to decipher the genetic changes associated with tumor
initiation and progression,. However, widespread clinical application of this information is …

Abstract The International Cancer Genome Consortium (ICGC) aims to catalog genomic
abnormalities in tumors from 50 different cancer types. Genome sequencing reveals …

It is widely accepted that cancer is a disease caused by accumulation of mutations in
specific genes. These tumor-specific mutations provide clues to the cellular processes …

Background With the onset of next-generation sequencing technologies, we have made
great progress in identifying recurrent mutational drivers of cancer. As cancer tissues are …

The cancer genome is moulded by the dual processes of somatic mutation and selection.
Homozygous deletions in cancer genomes occur over recessive cancer genes, where they …

The collective somatic mutations observed in a cancer are the outcome of multiple
mutagenic processes that have been operative over the lifetime of a patient. Each process …

Cancers develop as a result of driver mutations, that lead to clonal outgrowth and the
evolution of disease,. The discovery and functional characterization of individual driver …

Mutational signatures are patterns of mutations that arise during tumorigenesis. We present
an enhanced, practical framework for mutational signature analyses. Applying these …

Despite extraordinary efforts to profile cancer genomes, interpreting the vast amount of
genomic data in the light of cancer evolution remains challenging. Here we demonstrate that …

Recent large-scale cancer sequencing studies have focused primarily on identifying cancer-
associated genes, but as an important byproduct provide “passenger mutation” data that can …