The mitochondrial genome has been difficult to manipulate because it is shielded by the
organelle double membranes, preventing efficient nucleic acid entry. Moreover …

Mitochondria are responsible for the efficient conversion of the potential energy available in
sugars. However, like all biological processes, errors or incomplete reactions can occur …

The mitochondrial genome is a significant target of exogenous and endogenous genotoxic
agents; however, the determinants that govern this susceptibility and the pathways available …

Endonuclease G (EndoG) is a nuclear-encoded endonuclease, mostly localised in
mitochondria. In the nucleus EndoG participates in site-specific cleavage during replication …

In contrast to textbook pictures of bean-shaped blobs, mitochondria form a dynamic network
of interconnected tubules in many cell types that may fall apart into smaller individual units …

Although the nuclear processes responsible for genomic DNA replication and repair are well
characterized, the pathways involved in mitochondrial DNA (mtDNA) replication and repair …

Mitochondrial DNA (mtDNA) is located close to the respiratory chain, a major source of
reactive oxygen species (ROS). This proximity makes mtDNA more vulnerable than nuclear …

The different cell types of multicellular organisms have specialized physiological
requirements, affecting also their mitochondrial energy production and metabolism. The …

The mitochondrial genome is a matrilineally inherited DNA that encodes numerous essential
subunits of the respiratory chain in all metazoans. As such mitochondrial DNA (mtDNA) …

Mitochondrial genome integrity is fundamental to mammalian cell viability. Since
mitochondrial DNA is constantly under attack from oxygen radicals released during ATP …