Tryptophan catabolism through the kynurenine pathway generates a variety of bioactive
metabolites. Physical exercise can modulate kynurenine pathway metabolism in skeletal …

BACKGROUND The essential amino acid tryptophan is a substrate for the generation of
several bioactive compounds with important physiological roles. Only a small fraction of …

Emerging evidence highlights the substantial role of the kynurenine pathway in various
physiological systems and pathological conditions. Physical exercise has been shown to …

Tryptophan (TRP) is an essential amino acid. Metabolites of TRP have been identified as
important mediators in immune regulation and function of the central nervous system …

Physical exercise has emerged as an alternative treatment for patients with depressive
disorder. Recent animal studies show that exercise protects from depression by increased …

Background Systemic kynurenine levels are associated with resistance to stress‐induced
depression and are modulated by exercise. Tryptophan is a precursor for serotonin and …

Exercise positively impacts mood and symptoms of depression; however, the mechanisms
underlying these effects are not fully understood. Recent evidence highlights a potential role …

Obesity ultimately results from an imbalance between energy intake and expenditure.
However, in addition to their bioenergetic value, nutrients and their metabolites can function …

Introduction: The essential amino acid tryptophan (TRP) is primarily degraded through the
kynurenine (KYN) pathway, which is dysregulated in several chronic diseases. KYN …

In mammalian cells, the essential amino acid tryptophan is degraded primarily by the
kynurenine pathway, a cascade of enzymatic steps containing several biologically active …