Roots to start research in amyotrophic lateral sclerosis: molecular pathways and novel therapeutics for future
D Harikrishnareddy, S Misra, S Upadhyay… - Reviews in the …, 2015 - degruyter.com
Amyotrophic lateral sclerosis (ALS) is a devastating neurological disease that rapidly
progresses from mild motor symptoms to severe motor paralysis and premature death. There …
progresses from mild motor symptoms to severe motor paralysis and premature death. There …
New therapeutic targets for amyotrophic lateral sclerosis
M Kuzma-Kozakiewicz, H Kwiecinski - Expert opinion on …, 2011 - Taylor & Francis
Introduction: Amyotrophic lateral sclerosis (ALS) is one of the most devastating neurological
disorders, affecting approximately half a million people worldwide. Currently there is no cure …
disorders, affecting approximately half a million people worldwide. Currently there is no cure …
Amyotrophic lateral sclerosis: current therapeutic perspectives
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, characterized by
progressive motor neuron degeneration, muscle weakness, paralysis, and ultimately death …
progressive motor neuron degeneration, muscle weakness, paralysis, and ultimately death …
Emerging drugs for amyotrophic lateral sclerosis
AA Habib, H Mitsumoto - Expert opinion on emerging drugs, 2011 - Taylor & Francis
Introduction: Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative
disease that results in increasing disability and that is uniformly fatal. Since its approval in …
disease that results in increasing disability and that is uniformly fatal. Since its approval in …
Molecular insights and therapeutic targets in amyotrophic lateral sclerosis
A Al-Chalabi, VB Tripathi - CNS & Neurological Disorders-Drug …, 2008 - ingentaconnect.com
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of motor neurons
resulting in progressive paralysis and respiratory failure. About 1 in every 400 people dies of …
resulting in progressive paralysis and respiratory failure. About 1 in every 400 people dies of …
Diagnosis, pathogenesis and therapeutic targets in amyotrophic lateral sclerosis
J Costa, C Gomes… - CNS & Neurological …, 2010 - ingentaconnect.com
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease of the motor
system. The diagnosis is clinical, but additional investigations such as electromyography …
system. The diagnosis is clinical, but additional investigations such as electromyography …
Epigenetic mechanisms of gene regulation in amyotrophic lateral sclerosis
Despite being clinically described 150 years ago, the mechanisms underlying amyotrophic
lateral sclerosis (ALS) pathogenesis have not yet been fully understood. Studies in both …
lateral sclerosis (ALS) pathogenesis have not yet been fully understood. Studies in both …
[HTML][HTML] Recent advances in understanding amyotrophic lateral sclerosis and emerging therapies
LM Gittings, R Sattler - Faculty reviews, 2020 - ncbi.nlm.nih.gov
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that is
characterized by degeneration of both upper and lower motor neurons and subsequent …
characterized by degeneration of both upper and lower motor neurons and subsequent …
Molecular and cellular mechanisms affected in ALS
L Le Gall, E Anakor, O Connolly… - Journal of personalized …, 2020 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a terminal late-onset condition characterized by the
loss of upper and lower motor neurons. Mutations in more than 30 genes are associated to …
loss of upper and lower motor neurons. Mutations in more than 30 genes are associated to …
ALS drug development: reflections from the past and a way forward
S Aggarwal, M Cudkowicz - Neurotherapeutics, 2008 - Springer
Tremendous advances in our understanding of pathogenesis of amyotrophic lateral
sclerosis (ALS) have provided a rich pipeline of drugs for clinical trialists. At least 32 unique …
sclerosis (ALS) have provided a rich pipeline of drugs for clinical trialists. At least 32 unique …