Roots to start research in amyotrophic lateral sclerosis: molecular pathways and novel therapeutics for future

D Harikrishnareddy, S Misra, S Upadhyay… - Reviews in the …, 2015 - degruyter.com
Amyotrophic lateral sclerosis (ALS) is a devastating neurological disease that rapidly
progresses from mild motor symptoms to severe motor paralysis and premature death. There …

New therapeutic targets for amyotrophic lateral sclerosis

M Kuzma-Kozakiewicz, H Kwiecinski - Expert opinion on …, 2011 - Taylor & Francis
Introduction: Amyotrophic lateral sclerosis (ALS) is one of the most devastating neurological
disorders, affecting approximately half a million people worldwide. Currently there is no cure …

Amyotrophic lateral sclerosis: current therapeutic perspectives

V Kumar, T Kashav, MI Hassan - Pathology, prevention and therapeutics …, 2019 - Springer
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, characterized by
progressive motor neuron degeneration, muscle weakness, paralysis, and ultimately death …

Emerging drugs for amyotrophic lateral sclerosis

AA Habib, H Mitsumoto - Expert opinion on emerging drugs, 2011 - Taylor & Francis
Introduction: Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative
disease that results in increasing disability and that is uniformly fatal. Since its approval in …

Molecular insights and therapeutic targets in amyotrophic lateral sclerosis

A Al-Chalabi, VB Tripathi - CNS & Neurological Disorders-Drug …, 2008 - ingentaconnect.com
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of motor neurons
resulting in progressive paralysis and respiratory failure. About 1 in every 400 people dies of …

Diagnosis, pathogenesis and therapeutic targets in amyotrophic lateral sclerosis

J Costa, C Gomes… - CNS & Neurological …, 2010 - ingentaconnect.com
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease of the motor
system. The diagnosis is clinical, but additional investigations such as electromyography …

Epigenetic mechanisms of gene regulation in amyotrophic lateral sclerosis

A Jimenez-Pacheco, JM Franco, S Lopez… - … in Aging and Disease, 2017 - Springer
Despite being clinically described 150 years ago, the mechanisms underlying amyotrophic
lateral sclerosis (ALS) pathogenesis have not yet been fully understood. Studies in both …

[HTML][HTML] Recent advances in understanding amyotrophic lateral sclerosis and emerging therapies

LM Gittings, R Sattler - Faculty reviews, 2020 - ncbi.nlm.nih.gov
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that is
characterized by degeneration of both upper and lower motor neurons and subsequent …

Molecular and cellular mechanisms affected in ALS

L Le Gall, E Anakor, O Connolly… - Journal of personalized …, 2020 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a terminal late-onset condition characterized by the
loss of upper and lower motor neurons. Mutations in more than 30 genes are associated to …

ALS drug development: reflections from the past and a way forward

S Aggarwal, M Cudkowicz - Neurotherapeutics, 2008 - Springer
Tremendous advances in our understanding of pathogenesis of amyotrophic lateral
sclerosis (ALS) have provided a rich pipeline of drugs for clinical trialists. At least 32 unique …