Recent years have witnessed a renewed interest in the pathogenic mechanisms of
amyotrophic lateral sclerosis (ALS), a late-onset progressive degeneration of motor neurons …

Since amyotrophic lateral sclerosis (ALS) was discovered and described in 1869 as a
neurodegenerative disease in which motor neuron death is induced, a wide range of …

Because treatments are not yet powerful enough to reverse the symptoms of amyotrophic
lateral sclerosis (ALS), randomized placebo-controlled trials remain the gold standard for …

Research and key discoveries in the field of amyotrophic lateral sclerosis (ALS) have
exponentially increased since the announcement in 1993 of the first ALS-causing mutations …

Amyotrophic lateral sclerosis (ALS) is a complex, neurodegenerative disorder in which
alterations in structural, physiological, and metabolic parameters act synergistically. Over the …

Amyotrophic lateral sclerosis (ALS) is a genetically diverse disease. At least 15 ALS-
associated gene loci have so far been identified, and the causative gene is known in …

Amyotrophic lateral sclerosis (ALS) is characterized by the selective death of motor neurons
in the motor cortex, brainstem and spinal cord. It is a neurodegenerative disorder with high …

Amyotrophic lateral sclerosis (ALS) is a lethal degenerative disorder of motoneurons, which
may occur concurrently with frontotemporal dementia. Genetic analyses of the∼ 10% of ALS …

Amyotrophic lateral sclerosis (ALS) is an adult-onset motor neuron disease characterized by
degeneration of motor neuron and glial activation followed by the progressive muscle loss …