Background A new subgroup of HIV-1, designated Group P, was recently detected in two
unrelated patients of Cameroonian origin. HIV-1 Group P phylogenetically clusters with …

Background HIV-1 viruses are categorized into four distinct groups: M, N, O and P. Despite
the same genomic organization, only the group M viruses are responsible for the world-wide …

Most simian immunodeficiency viruses use their Nef protein to antagonize the host
restriction factor tetherin. A deletion in human tetherin confers Nef resistance, representing a …

Although Nef is the viral gene product used by most simian immunodeficiency viruses to
overcome restriction by tetherin, this activity was acquired by the Vpu protein of HIV-1 group …

The host restriction factor tetherin inhibits virion release from infected cells and poses a
significant barrier to successful zoonotic transmission of primate lentiviruses to humans …

Vpu proteins of pandemic HIV-1 M strains degrade the viral receptor CD4 and antagonize
human tetherin to promote viral release and replication. We show that Vpus from SIVgsn …

Background The anti-viral activity of the cellular restriction factor, BST-2/tetherin, was first
observed as an ability to block the release of Vpu-minus HIV-1 from the surface of infected …

Simian immunodeficiency viruses (SIVs) use their Nef proteins to counteract the restriction
factor tetherin. However, a deletion in human tetherin prevents antagonism by the Nef …

HIV-1 groups M and N emerged within the last century following two independent cross-
species transmissions of SIVcpz from chimpanzees to humans. In contrast to pandemic …

The mammalian antiviral membrane protein tetherin (BST2/CD317) can be expressed as
two isoforms derived from differential translational initiation. The shorter isoform of the …