HIV-1 Group P is unable to antagonize human tetherin by Vpu, Env or Nef
Background A new subgroup of HIV-1, designated Group P, was recently detected in two
unrelated patients of Cameroonian origin. HIV-1 Group P phylogenetically clusters with …
unrelated patients of Cameroonian origin. HIV-1 Group P phylogenetically clusters with …
Lack of adaptation to human tetherin in HIV-1 group O and P
SJ Yang, LA Lopez, CM Exline, KG Haworth… - Retrovirology, 2011 - Springer
Background HIV-1 viruses are categorized into four distinct groups: M, N, O and P. Despite
the same genomic organization, only the group M viruses are responsible for the world-wide …
the same genomic organization, only the group M viruses are responsible for the world-wide …
Nef proteins of epidemic HIV-1 group O strains antagonize human tetherin
Most simian immunodeficiency viruses use their Nef protein to antagonize the host
restriction factor tetherin. A deletion in human tetherin confers Nef resistance, representing a …
restriction factor tetherin. A deletion in human tetherin confers Nef resistance, representing a …
Tetherin antagonism by HIV-1 group M Nef proteins
JF Arias, M Colomer-Lluch, B von Bredow… - Journal of …, 2016 - Am Soc Microbiol
Although Nef is the viral gene product used by most simian immunodeficiency viruses to
overcome restriction by tetherin, this activity was acquired by the Vpu protein of HIV-1 group …
overcome restriction by tetherin, this activity was acquired by the Vpu protein of HIV-1 group …
Preadaptation of simian immunodeficiency virus SIVsmm facilitated Env-mediated counteraction of human tetherin by human immunodeficiency virus type 2
E Heusinger, K Deppe, P Sette, C Krapp… - Journal of …, 2018 - Am Soc Microbiol
The host restriction factor tetherin inhibits virion release from infected cells and poses a
significant barrier to successful zoonotic transmission of primate lentiviruses to humans …
significant barrier to successful zoonotic transmission of primate lentiviruses to humans …
Tetherin-driven adaptation of Vpu and Nef function and the evolution of pandemic and nonpandemic HIV-1 strains
D Sauter, M Schindler, A Specht, WN Landford… - Cell host & …, 2009 - cell.com
Vpu proteins of pandemic HIV-1 M strains degrade the viral receptor CD4 and antagonize
human tetherin to promote viral release and replication. We show that Vpus from SIVgsn …
human tetherin to promote viral release and replication. We show that Vpus from SIVgsn …
Anti-tetherin activities in Vpu-expressing primate lentiviruses
SJ Yang, LA Lopez, H Hauser, CM Exline, KG Haworth… - Retrovirology, 2010 - Springer
Background The anti-viral activity of the cellular restriction factor, BST-2/tetherin, was first
observed as an ability to block the release of Vpu-minus HIV-1 from the surface of infected …
observed as an ability to block the release of Vpu-minus HIV-1 from the surface of infected …
Efficient Vpu-mediated tetherin antagonism by an HIV-1 group O strain
K Mack, K Starz, D Sauter, S Langer… - Journal of …, 2017 - Am Soc Microbiol
Simian immunodeficiency viruses (SIVs) use their Nef proteins to counteract the restriction
factor tetherin. However, a deletion in human tetherin prevents antagonism by the Nef …
factor tetherin. However, a deletion in human tetherin prevents antagonism by the Nef …
Human tetherin exerts strong selection pressure on the HIV-1 group N Vpu protein
D Sauter, D Unterweger, M Vogl, SM Usmani… - PLoS …, 2012 - journals.plos.org
HIV-1 groups M and N emerged within the last century following two independent cross-
species transmissions of SIVcpz from chimpanzees to humans. In contrast to pandemic …
species transmissions of SIVcpz from chimpanzees to humans. In contrast to pandemic …
Differential sensitivities of tetherin isoforms to counteraction by primate lentiviruses
J Weinelt, SJD Neil - Journal of virology, 2014 - Am Soc Microbiol
The mammalian antiviral membrane protein tetherin (BST2/CD317) can be expressed as
two isoforms derived from differential translational initiation. The shorter isoform of the …
two isoforms derived from differential translational initiation. The shorter isoform of the …