The replisome, the molecular machine dedicated to copying DNA, encounters a variety of
obstacles during S phase. Without a proper response to this replication stress, the genome …

The protection and efficient restart of stalled replication forks is critical for the maintenance of
genome integrity. Here, we identify a regulatory pathway that promotes stalled forks recovery …

During genome replication, replication forks often encounter obstacles that impede their
progression. Arrested forks are unstable structures that can give rise to collapse and …

To ensure the completion of DNA replication and maintenance of genome integrity, DNA
repair factors protect stalled replication forks upon replication stress. Previous studies have …

Accurate duplication of chromosomal DNA is essential for the transmission of genetic
information. The DNA replication fork encounters template lesions, physical barriers …

Accurate transmission of the genetic information requires complete duplication of the
chromosomal DNA each cell division cycle. However, the idea that replication forks would …

Fork reversal is a common response to replication stress, but it generates a DNA end that is
susceptible to degradation. Many fork protection factors block degradation, but how they …

Maintaining genome stability is essential for the accurate transmission of genetic material.
Genetic instability is associated with human genome disorders and is a near-universal …

The ATR replication checkpoint ensures that stalled forks remain stable when replisome
movement is impeded. Using an improved iPOND protocol combined with SILAC mass …

Aberrant DNA replication is a major source of the mutations and chromosome
rearrangements that are associated with pathological disorders. When replication is …