Rho-associated kinases (ROCKs), the immediate downstream targets of RhoA, are
ubiquitously expressed serine-threonine protein kinases that are involved in diverse cellular …

The Rho kinase (ROCK) isoforms, ROCK1 and ROCK2, were initially discovered as
downstream targets of the small GTP-binding protein Rho. Because ROCKs mediate various …

Rho-associated kinases ROCK1 and ROCK2 are serine/threonine kinases that are
downstream targets of the small GTPases RhoA, RhoB, and RhoC. ROCKs are involved in …

Rho kinases (ROCKs) are the first and the best-characterized effectors of the small G-protein
RhoA. In addition to their effect on actin organization, or through this effect, ROCKs have …

ROCKs are important regulators of the actin cytoskeleton. Because changes in the actin
cytoskeleton underlie vascular contractility and remodeling, inflammatory cell recruitment …

Rho kinase (ROCK) belongs to the AGC (PKA/PKG/PKC) family of serine/threonine kinases
and is a major downstream effector of the small GTPase RhoA. ROCK plays central roles in …

Atherosclerosis is a complex inflammatory process characterized by the cross-talk between
excessive inflammation and lipid accumulation. In the past few years, compelling evidence …

Rho-kinase (ROCK) is one of the downstream effectors of the small G-protein Rho. The Rho–
ROCK pathway has an important role in mediating various cellular functions, including …

Abstract Significance: The 3-hydroxy-methylglutaryl coenzyme A reductase inhibitors or
statins are important therapeutic agents for lowering serum cholesterol levels. However …

Rho kinase (ROCK) belongs to a family of Ser/Thr protein kinases that are activated via
interaction with the small GTP-binding protein RhoA. Growing evidence suggests that RhoA …