Leptin has received considerable attention as a newly recognized metabolic hormone and
for its potential for therapeutic use in the treatment of human obesity. Furthermore, defects in …

Leptin, the product of the adipose tissue-specific ob gene, is a newly recognized hormone
involved in the regulation of metabolism and body composition. Leptin appears to provide …

Leptin, discovered through positional cloning 15 years ago, is an adipocyte-secreted
hormone with pleiotropic effects in the physiology and pathophysiology of energy …

THE DISCOVERY of leptin in 1994 has provided a major new piece in the puzzle of obesity.
Leptin is a 167-amino acid peptide made exclusively in adipose tissue. Its absence …

The high prevalence of obesity and its well documented association with the cardiovascular
risk factors diabetes mellitus, dyslipidemia and hypertension represents a major problem for …

Obesity results from an abnormal accumulation of fat in the white adipose tissue. Recent
research utilizing genetic models of obesity in rodents has implicated a major role of leptin …

Leptin, the product of the Lep gene (originally termed ob gene), was discovered through
positional cloning techniques employed to determine the genetic defect resulting in obesity …

The identification and sequencing of the ob gene and its product, leptin, in late 1994 opened
new insights in the study of the mechanisms controlling body weight and led to a surge of …

Leptin is a 16-kDa cytokine secreted in humans primarily but not exclusively by adipose
tissues. Its concentration in blood is usually proportional to body fat mass, but is higher in …

Recent advances indicate that a robust physiologic system acts to maintain relative
constancy of weight in mammals. A key component of this system is leptin. Leptin is an …