Purpose We aimed to conduct a double-blind randomized controlled pragmatic trial to
evaluate the effects of off-the-shelf leucine metabolite supplements of α-HICA, HMB-FA, and …

Abstract β-hydroxy-β-methylbutyrate (calcium: HMB-Ca and free acid: HMB-FA) and α-
hydroxyisocaproic acid (α-HICA) are leucine metabolites that have been proposed to …

Branched-chain amino acids (BCAA) are one of the most popular sports supplements,
marketed under the premise that they enhance muscular adaptations. Despite their …

The purpose of this study was to examine the effects of free leucine supplementation on
changes in skeletal muscle mass and strength during a resistance training (RT) program in …

Ingestion of proteins with high leucine content during resistance training (RT) can augment
hypertrophy. Some data suggest that a leucine metabolite, β-hydroxy, β-methylbutyrate …

Alongside a proper diet, ergogenic aids with potential direct and/or indirect physical
performance enhancing effects are sought after for improved adaptation to physical training …

Essential amino acids (EAA) stimulate skeletal muscle protein synthesis (MPS) in humans.
Leucine may have a greater stimulatory effect on MPS than other EAA and/or decrease …

Skeletal muscle protein synthesis (MPS) is regulated by a number of dietary factors, to
include essential amino acids (EAAs). Leucine, a branched-chain amino acid, has been …

Leucine, isoleucine and valine, the branched-chain amino acids (BCAA), make up about
one-third of muscle protein. Of these, leucine has been the most thoroughly investigated …

Context: Of the 3 branched-chain amino acids (BCAA), leucine has arguably received the
most attribution for the role of BCAA supplementation in alleviating symptoms of exercise …