The development of biomimetic bone graft materials for periodontal tissue engineering is a
field of topical interest. In this study, we designed a dual-functionalized apatite …

Objectives: 1) Develop a novel construct of human periodontal ligament stem cells
(hPDLSCs) encapsulated in degradable alginate microbeads (DAMB) with human platelet …

Methods Herein, a facile and green design of engineered bone graft materials was
developed by integrating a biomimetic apatite nanocomposite with a smart-release coating …

Periodontal bone defect is a common but longstanding healthcare issue since traditional
bone grafts have limited functionalities in regulating complex intraoral microenvironments …

Tissue engineering technology provides a new method for periodontal regeneration. Finding
or preparing a suitable scaffold is the key to periodontal tissue engineering. Here, we use …

Guided bone regeneration (GBR) technology has been widely used for the regeneration of
periodontal bone defects. However, the limited mechanical properties and bone …

Introduction Natural bone has a complex hierarchical nanostructure composed of well-
organized collagen fibrils embedded with apatite crystallites. Bone tissue engineering …

Objectives: Stem cell-based tissue engineering approaches are promising for bone repair
and regeneration. Periodontal ligament stem cells (PDLSCs) are a promising cell source for …

Stem cell therapy might be a promising method to stimulate alveolar bone regeneration,
which is currently a major clinical challenge. However, its therapeutic features largely …

Inflammation-related bone defects often lead to poor osteogenesis. Therefore, it is crucial to
reduce the inflammation response and promote the osteogenic differentiation of …