Hydrogels are three‐dimensional (3D) scaffolds able to embed cells and deliver
biomolecules to promote tissue repair. These 3D matrices provide a temporary support to …

Enzyme-manipulated hydrogelation based on self-assembly of small molecules is an
attractive methodology for development of functional biomaterials. Upon the catalysis of …

Enzymes play a central role in fundamental biological processes and have been traditionally
used to trigger various processes. In recent years, enzymes have been used to tune …

State-of-the-art bioactive hydrogels can easily and efficiently be formed by enzyme-
catalyzed mild-crosslinking reactions in situ. Yet this cell-friendly and substrate-specific …

The expression and distribution of enzymes differ by the types and states of cells, tissues,
and organs, thus leading to diverse extracellular and intracellular environments. Using an …

Self-assembled structures primarily arise through enzyme-regulated phenomena in nature
under persistent conditions. Enzymatic reactions are one of the main biological processes …

Crosslinking is a fundamental aspect of hydrogel formation and plays an essential role in the
subsequent hydrogel properties in terms of mechanical and chemical stability. Enzyme …

Conspectus Enzymes, a class of highly efficient and specific catalysts in Nature, dictate a
myriad of reactions that constitute various cascades in biological systems. There is growing …

The quest to develop state-of-the-art hydrogels for bone tissue engineering has
accompanied substantial innovation and significant progression in the field of bioactive …

Until recently, the tissue regeneration approaches typically relied on three essential
components: scaffolds, designed to maintain the cells in a threedimensional environment; …