Dual stimulation of MyD88-dependent Toll-like receptors induces synergistically enhanced production of inflammatory cytokines in murine bone marrow-derived …

D Mitchell, M Yong, W Schroder, M Black… - The Journal of …, 2010 - academic.oup.com
Abstract Background. Triggering Toll-like receptors (TLRs) on dendritic cells (DCs) induces
inflammatory cytokine production necessary for T helper type 1 immunity. The present study …

Regulation of Toll-like receptor-induced chemokine production in murine dendritic cells by mitogen-activated protein kinases

D Mitchell, C Olive - Molecular immunology, 2010 - Elsevier
Production of chemokines in dendritic cells (DCs) may be crucial in modulating immune
responses generated through Toll-like receptor (TLR)-mediated recognition of microbial …

Toll-like receptor (TLR) 2 and TLR3 synergy and cross-inhibition in murine myeloid dendritic cells

F Vanhoutte, C Paget, L Breuilh, J Fontaine… - Immunology letters, 2008 - Elsevier
Toll-like receptors (TLRs) play an important role in the innate recognition of pathogens by
dendritic cells (DCs) and in the induction of immune responses. Few studies have been …

Activation of toll-like receptor 2 on human dendritic cells triggers induction of IL-12, but not IL-10

S Thoma-Uszynski, SM Kiertscher… - The Journal of …, 2000 - journals.aai.org
Abstract Mammalian Toll-like receptors (TLRs) are required for cell activation by bacterial
lipoproteins (bLP) and LPS. Stimulation of monocytes with bLP and LPS results in a TLR …

Toll-like receptor 2 (TLR2) and TLR4 differentially activate human dendritic cells

F Re, JL Strominger - Journal of Biological Chemistry, 2001 - ASBMB
Toll-like receptors (TLRs) mediate cell activation by various microbial products. Here, we
demonstrate that activation of dendritic cells by TLR2 or TLR4 agonists, although it led to …

Synergism of Toll-like receptor-induced interleukin-12p70 secretion by monocyte-derived dendritic cells is mediated through p38 MAPK and lowers the threshold of T …

HR Bohnenkamp, KT Papazisis, JM Burchell… - Cellular …, 2007 - Elsevier
Toll-like receptors (TLRs) recognise specific molecular signatures of pathogens and trigger
antimicrobial defence responses. Thereby, two independent signalling pathways can be …

Synergistic activation of dendritic cells by combined Toll-like receptor ligation induces superior CTL responses in vivo

T Warger, P Osterloh, G Rechtsteiner, M Fassbender… - Blood, 2006 - ashpublications.org
Toll-like receptors (TLRs) are able to interact with pathogen-derived products and their
signals induce the coordinated activation of innate and adaptive immune mechanisms …

Endotoxin can induce MyD88‐deficient dendritic cells to support Th2 cell differentiation

T Kaisho, K Hoshino, T Iwabe, O Takeuchi… - International …, 2002 - academic.oup.com
Toll‐like receptor (TLR) signaling activates dendritic cells (DC) to secrete proinflammatory
cytokines and up‐regulate co‐stimulatory molecule expression, thereby linking innate and …

Differential regulation of Toll‐like receptor signalling in spleen and Peyer's patch dendritic cells

JM Davies, J MacSharry, F Shanahan - Immunology, 2010 - Wiley Online Library
Toll‐like receptor (TLR) signalling shapes dendritic cell (DC) responses by inducing co‐
stimulatory molecule up‐regulation and cytokine secretion while TLR regulatory proteins …

Differential induction of interleukin-10 and interleukin-12 in dendritic cells by microbial toll-like receptor activators and skewing of T-cell cytokine profiles

H Qi, TL Denning, L Soong - Infection and immunity, 2003 - Am Soc Microbiol
Dendritic cells (DCs) discriminate different microbial pathogens and induce T-cell responses
of appropriate effector phenotypes accordingly. Microbial recognition and differentiation are …