Targeted protein degradation has exploded over the past several years due to preclinical
and early clinical therapeutic success of numerous compounds, and the emergence of new …

Proteolysis targeting chimeras are bifunctional small molecules capable of recruiting a target
protein of interest to an E3 ubiquitin ligase that facilitates target ubiquitination followed by …

The ubiquitin ligase complex SCFFbs1, which contributes to the ubiquitination of
glycoproteins, is involved in the endoplasmic reticulum-associated degradation pathway. In …

Prp19 is an essential splicing factor and a member of the U-box family of E3 ubiquitin
ligases. Prp19 forms a tetramer via a central coiled-coil domain. Here, we show the U-box …

Thalidomide and its derivatives lenalidomide and pomalidomide (IMiDs) are effective
treatments of haematologic malignancies. It was shown that IMiDs impart gain-of-function …

Inducing protein degradation via small molecules is a transformative therapeutic paradigm.
Although structural requirements of target degradation are emerging, mechanisms …

Highlights•E3 ligases recruit substrates for proteasomal degradation by recognition of
degrons.•Crystal structures reveal the structural basis and mechanism of degron …

Recent evidence has revealed that senescence induction requires fine-tuned activation of
p53, however, mechanisms underlying the regulation of p53 activity during senescence …

N-glycosylation of proteins in the endoplasmic reticulum (ER) has a central role in protein
quality control,,. Here we report that N-glycan serves as a signal for degradation by the Skp1 …

In the last decade, the ubiquitin–proteasome system has emerged as a valid target for the
development of novel therapeutics. E3 ubiquitin ligases are particularly attractive targets …