OBJECTIVE: Euthyroid sick syndrome is a common finding in critically ill patients with
nonthyroidal illness, characterized by low serum levels of free triiodothyronine (fT3) with a …

Context: Critical illness, an extreme form of severe physical stress, is characterized by
important endocrine and metabolic changes. Due to critical care medicine, survival from …

Despite the considerable advances made in understanding the pathophysiology of systemic
inflammation during critical illness, clinical progress has been elusive as it remains a very …

Adaptations to critical illness result in several commonly encountered clinical scenarios in
patients with and without underlying endocrine conditions. These situations often pose …

Critically ill patients show a variety of hormonal changes that appear to differ considerably in
acute and prolonged critical illness. Whether these endocrine alterations serve as …

Objective: To determine whether cytokine release or activation of the hypothalamo-pituitary-
adrenal (HPA) axis is predominantly involved in the development of the euthyroid sick …

Acute and chronic critical conditions are associated with reduced serum levels of free
triiodothyronine (FT3), free thyroxine FT4, and thyrotropin, known as nonthyroidal illness …

We studied the ability of thyroid function tests to predict hospital survival in 116 critically ill
patients and compared the results with independent predictions of survival made by critical …

• We studied the hormonal milieu and possibility of altered thyroid function in 25 patients in a
surgical intensive care unit (ICU) who had severe life-threatening illnesses. Sixteen patients …

Context: Both critical illness and fasting induce low circulating thyroid hormone levels in the
absence of a rise in TSH, a constellation-labeled nonthyroidal illness syndrome (NTI). The …