Aims/hypothesis Homo sapiens evolved under conditions of intermittent food availability and
prolonged fasting between meals. Periods of fasting are important for recovery from meal …

Aims/hypothesis Nutrient overabundance and diminished physical activity underlie the
epidemic of obesity and its consequences of insulin resistance and type 2 diabetes. These …

The rising incidence of diabetes, metabolic syndrome, and subsequent vascular diseases is
now a major public health problem in industrialized countries. New therapeutic strategies to …

Diabetic retinopathy (DR) is a complication secondary to diabetes and is the number one
cause of blindness among working age individuals worldwide. Despite recent therapeutic …

Abstract Mammalian sirtuin 6 (SIRT6) is involved in the regulation of many essential
processes, especially metabolic homeostasis. SIRT6 knockout mice undergo premature …

Diabetes is a chronic metabolic disorder with a high rate of morbidity and mortality.
Insufficient insulin secretion and insulin action are two major causes for the development of …

Objective SIRT1 has been proposed to be a key signaling node linking changes in energy
metabolism to transcriptional adaptations. Although SIRT1 overexpression is protective …

Caloric restriction (CR) has been shown to prevent the onset of insulin resistance and to
delay age-related physiological decline in mammalian organisms. SIRT1, a NAD+ …

The prevalence of type 2 diabetes mellitus (T2DM) has been increasing worldwide.
Therefore, a novel therapeutic strategy by which to prevent T2DM is urgently required …

Intermittent fasting (IF) is gaining popularity for its effectiveness in improving overall health,
including its effectiveness in achieving weight loss and euglycemia. The molecular …