Diet affects health through ingested calories and macronutrients, and macronutrient balance
affects health span. The mechanisms regulating macronutrient-based diet choices are …

The specific Sirt1 activator SRT1720 increases mitochondrial function in skeletal muscle,
presumably by activating Sirt1. However, Sirt1 gain of function does not increase …

Scope Mice with deletion of insulin receptor substrate (IRS) 2 develop hyperglycaemia,
impaired hepatic insulin signaling and elevated gluconeogenesis. Protein tyrosine …

Background We have previously shown leucine (Leu) to activate Sirt1 by lowering its KM for
NAD+, thereby amplifying the effects of other sirtuin activators and improving insulin …

The NAD+-dependent deacetylase SIRT1 controls metabolic processes in response to low
nutrient availability. We report the metabolic phenotype of mice treated with SRT1720, a …

Induction of β-cell regeneration from endogenous cells represents a highly promising
strategy in stem cell-based treatment for patients with diabetes. Recently, calorie restriction …

Aims/hypothesis The mechanisms underlying the cellular metabolic memory induced by
high glucose remain unclear. Here, we sought to determine the effects of microRNAs …

Abstract Sirtuin 1 (SIRT1) activation reduces oxidative stress, inhibits inflammatory
responses, and retards cellular senescence in endothelial cells in mouse models of …

Resveratrol mimics calorie restriction to extend lifespan of Caenorhabditis elegans, yeast
and Drosophila, possibly through activation of Sir2 (silent information regulator 2), a NAD+ …

Dysregulation of metabolic pathways leads to type 2 diabetes, characteristic of high glucose
concentration caused by insulin resistance. The histone deacetylases sirtuins exhibit …