Abstract The Nrd1–Nab3–Sen1 (NNS) complex integrates molecular cues to direct
termination of noncoding transcription in budding yeast. NNS is positively regulated by …

In Saccharomyces cerevisiae, the Nrd1-Nab3-Sen1 pathway mediates the termination of
snoRNAs and cryptic unstable transcripts (CUTs). Both Nrd1 and the Set1 histone H3K4 …

RNA polymerase II transcribes both coding and noncoding genes, and termination of these
different classes of transcripts is facilitated by different sets of termination factors. Pre …

The yeast Set1 histone H3 lysine 4 (H3K4) methyltransferase contains, in addition to its
catalytic SET domain, a conserved RNA recognition motif (RRM1). We present here the …

Abstract Background Nrd1 and Nab3 are essential sequence-specific yeast RNA binding
proteins that function as a heterodimer in the processing and degradation of diverse classes …

Background: Recent analyses implicate changes in the expression of the box C/D class of
small nucleolar RNAs (snoRNAs) in several human diseases. Methods: Here we report the …

A substantial part of living cells activity involves transcription regulation. The RNA
polymerases responsible for this job need to know 'where/when'to start and stop in the …

In Saccharomyces cerevisiae, H3 methylation at lysine 4 (H3K4) is mediated by Set1. Set1 is
a large protein bearing a conserved RNA recognition motif in addition to its catalytic C …

The Set1 family of histone H3 lysine 4 (H3K4) methyltransferases is highly conserved from
yeast to human. Here we show that the Set1 complex (Set1C) directly binds RNA in vitro …

Abstract SETD1A and SETD1B originate from Set1, the sole H3K4 methyltransferase in
yeast, and they play important roles in active gene transcription. Here, we present the crystal …