Ischaemic heart disease represents a restriction of blood, and therefore oxygen, supply to
the myocardium. This leads to a remodelling of cardiac metabolism, which can exacerbate …

Introduction Relative oxidation of different metabolic substrates in the heart varies both
physiologically and pathologically, in order to meet metabolic demands under different …

Aim: Obesity is a major contributor to the global burden of disease and is closely associated
with the development of type 2 diabetes and cardiovascular diseases. This study tested the …

The goal of this study was to determine whether changes in cardiac metabolism in Type 2
diabetes are associated with contractile dysfunction or impaired response to ischemia …

Developed countries are experiencing a diabetes epidemic, and approximately 80% of
diabetics die from heart disease. While the ultimate cause of heart failure remains unknown …

Cardiac ischemia and its consequences including heart failure, which itself has emerged as
the leading cause of morbidity and mortality in developed countries are accompanied by …

Key points Dysfunctional mitochondrial respiration may contribute to the establishment of
diabetic cardiomyopathy, but this remains controversial; resveratrol, a polyphenol …

A novel mechanism to ameliorate ischemia/reperfusion (I/R) injury and improve post-
ischemic functional recovery is the optimization of myocardial energy metabolism by shifting …

Aims Cardiac energy metabolism is perturbed in ischaemic heart failure and is characterized
by a shift from mitochondrial oxidative metabolism to glycolysis. Notably, the failing heart …

Aims Cardiovascular disease is the leading cause of mortality in people with type 2
diabetes. Following a myocardial infarction, the heart must adapt to the decreased oxygen …