Lower body negative pressure (LBNP) simulates hemorrhage in human subjects. Most
subjects (67%) exhibited high tolerance (HT) to hypovolemia, while the remainder (33%) …

Central hypovolemia elicited by orthostasis or hemorrhage triggers sympathetically-
mediated baroreflex responses to maintain organ perfusion; these reflexes are less sensitive …

Heat stress profoundly impairs tolerance to central hypovolemia in humans via a number of
mechanisms including heat-induced hypovolemia. However, heat stress also elevates …

This review presents lower body negative pressure (LBNP) as a unique tool to investigate
the physiology of integrated systemic compensatory responses to altered hemodynamic …

Purpose To test the hypothesis that those who are highly tolerant to lower body negative
pressure (LBNP) while normothermic are also highly tolerant to this challenge while …

Materials and Methods: There were 51 healthy participants who underwent a progressive
simulated hemorrhage to induce central hypovolemia by lower body negative pressure …

Tolerance to central hypovolemia is highly variable, and accumulating evidence suggests
that protection of anterior cerebral blood flow (CBF) is not an underlying mechanism. We …

The purpose of this investigation was to test the hypothesis that peripheral vasoconstriction
and orthostatic tolerance are associated with increased circulating plasma concentrations of …

Lower body negative pressure (LBNP) elicits central hypovolemia, and it has been used to
simulate the cardiovascular and cerebrovascular responses to hemorrhage in humans …

Trauma patients may suffer significant blood loss, and noninvasive methods to diagnose
hypovolemia in these patients are needed. Physiologic effects of hypovolemia, aiming to …