Follicular T helper cells shape the HCV-specific CD4+ T cell repertoire after virus elimination
BACKGROUND Chronic hepatitis C virus (HCV) infection is characterized by a severe
impairment of HCV-specific CD4+ T cell help that is driven by chronic antigen stimulation …
impairment of HCV-specific CD4+ T cell help that is driven by chronic antigen stimulation …
Virus-specific CD4+ T cells have functional and phenotypic characteristics of follicular T-helper cells in patients with acute and chronic HCV infections
B Raziorrouh, K Sacher, RG Tawar, F Emmerich… - Gastroenterology, 2016 - Elsevier
Background & Aims Follicular T-helper (Tfh) cells contribute to pathogen-specific antibody
responses by providing maturation signals to B cells. In mice with viral infections, virus …
responses by providing maturation signals to B cells. In mice with viral infections, virus …
Hepatitis C virus–specific CD4+ T cell phenotype and function in different infection outcomes
CD4+ T cell failure is a hallmark of chronic hepatitis C virus (HCV) infection. However, the
mechanisms underlying the impairment and loss of virus-specific CD4+ T cells in persisting …
mechanisms underlying the impairment and loss of virus-specific CD4+ T cells in persisting …
Suppression of HCV-specific T cells without differential hierarchy demonstrated ex vivo in persistent HCV infection
K Sugimoto, F Ikeda, J Stadanlick, FA Nunes, HJ Alter… - Hepatology, 2003 - Elsevier
Hepatitis C virus (HCV) has a high propensity for persistence. To better define the
immunologic determinants of HCV clearance and persistence, we examined the circulating …
immunologic determinants of HCV clearance and persistence, we examined the circulating …
Broadly directed virus-specific CD4+ T cell responses are primed during acute hepatitis C infection, but rapidly disappear from human blood with viral persistence
J Schulze zur Wiesch, D Ciuffreda… - Journal of Experimental …, 2012 - rupress.org
Vigorous proliferative CD4+ T cell responses are the hallmark of spontaneous clearance of
acute hepatitis C virus (HCV) infection, whereas comparable responses are absent in …
acute hepatitis C virus (HCV) infection, whereas comparable responses are absent in …
Elimination of hepatitis C virus has limited impact on the functional and mitochondrial impairment of HCV-specific CD8+ T cell responses
A Aregay, SO Sekyere, K Deterding, K Port, J Dietz… - Journal of …, 2019 - Elsevier
Background & Aims Hepatitis C virus (HCV)-specific CD8+ T cells are functionally impaired
in chronic hepatitis C. Even though HCV can now be rapidly and sustainably cleared from …
in chronic hepatitis C. Even though HCV can now be rapidly and sustainably cleared from …
Virus-specific CD4+ T cell responses in chronic HCV infection in blood and liver identified by antigen-specific upregulation of CD154
M Mueller, HC Spangenberg, N Kersting, T Altay… - Journal of …, 2010 - Elsevier
BACKGROUND & AIMS: Virus-specific CD4+ T cells play a major role in hepatitis C virus
(HCV) infection. Viral clearance is associated with vigorous and multispecific CD4+ T cell …
(HCV) infection. Viral clearance is associated with vigorous and multispecific CD4+ T cell …
CD8+ T cells of chronic HCV-infected patients express multiple negative immune checkpoints following stimulation with HCV peptides
Hepatitis C virus (HCV)-specific CD4+ and CD8+ T cells are key to successful viral
clearance in HCV disease. Accumulation of exhausted HCV-specific T cells during chronic …
clearance in HCV disease. Accumulation of exhausted HCV-specific T cells during chronic …
T Cells with a CD4+CD25+ Regulatory Phenotype Suppress In Vitro Proliferation of Virus-Specific CD8+ T Cells during Chronic Hepatitis C Virus Infection
T Boettler, HC Spangenberg… - Journal of …, 2005 - Am Soc Microbiol
Chronic hepatitis C virus (HCV) infection is associated with impaired proliferative, cytokine,
and cytotoxic effector functions of HCV-specific CD8+ T cells that probably contribute …
and cytotoxic effector functions of HCV-specific CD8+ T cells that probably contribute …
A heterogeneous hierarchy of co-regulatory receptors regulates exhaustion of HCV-specific CD8 T cells in patients with chronic hepatitis C
Background & Aims The functionality of virus-specific T cells is regulated by a sophisticated
network of an expanding repertoire of co-regulatory receptors, which could be harnessed for …
network of an expanding repertoire of co-regulatory receptors, which could be harnessed for …