Background Gabon is a malaria-threatened country with a stable and hyperendemic
transmission of Plasmodium falciparum monoinfection. Malaria drug resistance is widely …

Malaria remains a leading cause of morbidity and mortality in Burkina Faso, which utilizes
artemether–lumefantrine as the principal therapy to treat uncomplicated malaria and …

Background Plasmodium falciparum malaria remains a leading health problem in Africa and
its control is seriously challenged by drug resistance. Although resistance to the …

Background Mutations in the dihydrofolate reductase (dhfr) and dihydropteroate synthase
(dhps) genes of Plasmodium falciparum are associated with resistance to anti-folate drugs …

Antifolate drugs have an important role in the treatment of malaria. Polymorphisms in the
genes encoding the dihydrofolate reductase and dihydropteroate synthetase enzymes …

Background The malaria situation has been worsening in Angola, partly due to armed
conflict until the recent past and drug-resistant Plasmodium falciparum. Malaria transmission …

Purpose: The introduction of artemisinin-based combination therapies (ACTs) in treating
uncomplicated malaria and sulfadoxine–pyrimethamine (SP) as intermittent preventive …

A major challenge in the fight to effectively control malaria is the emergence of resistant
parasite to drugs used in therapy as well as for chemoprevention. In this study, single …

Objectives: This study was conducted to study the polymorphisms in antimalarial drug
resistance marker genes among clinical Plasmodium falciparum isolates collected from …

Background Sulfadoxine-pyrimethamine has been widely used as first-line therapy for
uncomplicated malaria throughout sub-Saharan Africa. Recent studies conducted in Asia …