Amiodarone is widely used to treat cardiac arrhythmias and is very effective in preventing
these disorders. However, its use is limited by a wide range of adverse effects, mainly …

Amiodarone (AD) is a highly efficient antiarrhythmic drug with potentially serious side effects.
Severe pulmonary toxicity is reported in patients receiving AD even at low doses and may …

Amiodarone (AD) is an iodinated benzofuran derivative, especially known for its
antiarrhythmic properties. It exerts serious side‐effects even in patients receiving low doses …

Amiodarone, an antiarrhythmic drug toxic toward the lung, is metabolized through sequential
modifications of the diethylaminoethoxy group to mono-N-desethylamiodarone (MDEA), di-N …

Abstract Treatment with the iodine-containing antiarrhythmic drug, amiodarone, can cause
pulmonary toxicity. Alveolar macrophages are particularly susceptible to formation of lipid …

Amiodarone (AD) is gaining support as a first-line antiarrhythmic drug despite its potentially
fatal pulmonary toxicity involving inflammation and fibrosis. We previously reported a model …

Background and purpose: Tissue deposits of the anti‐arrhythmic drug amiodarone are a
major source of side effects (skin discoloration, etc.). We addressed the mechanism of the …

Amiodarone-induced pulmonary toxicity is a serious side-effect, but the underlying
molecular mechanisms remain unclear. We examined phospholipidosis and apoptosis in rat …

Amiodarone is a clinically effective antiarrhythmic drug shown to cause lung damage in
humans and animals. While the mechanism of this pulmonary toxicity is unknown, it may be …

MATERIALS AND METHODS Chemicals AMD and DEA were kindly supplied by Taisho
Pharmaceutical (Tokyo, Japan). All other reagents were of the highest grade available and …