Infections of the central nervous system (CNS) are complex to treat and associated with
significant morbidity and mortality. Historically, antistaphylococcal penicillins such as …

Background The relative distribution of cefazolin into the cerebrospinal fluid (CSF) remains
debated. Determining the distribution of cefazolin into the CSF in noninfected adults may …

Objectives To assess the meningeal penetration of cefazolin and cloxacillin in individuals
treated for methicillin-susceptible staphylococcal meningitis. Methods We retrospectively …

Background Anti-staphylococcal penicillins have long been the first-line treatment option for
methicillin-susceptible Staphylococcus aureus (MSSA) infections. Recent retrospective data …

Recent studies and experience suggest that cefazolin might be equally as effective as
antistaphylococcal penicillins for methicillin-susceptible Staphylococcus aureus (MSSA) …

Background. Nafcillin and cefazolin are considered first-line therapy for most infections with
methicillin-susceptible Staphylococcus aureus (MSSA), and recent studies have suggested …

Abstract Introduction Methicillin-susceptible Staphylococcus aureus (MSSA) is a common
cause of infection in humans. Beta-lactam antibiotics are the preferred agents, with anti …

Recent observational studies have suggested possible reductions in mortality in patients
receiving cefazolin versus antistaphylococcal penicillins. We examined 90-day mortality in …

Nosocomial central nervous system (CNS) infections with carbapenem-and colistin-resistant
Gram-negative and vancomycin-resistant Gram-positive bacteria are an increasing …

Background To treat patients with methicillin-susceptible Staphylococcus aureus (MSSA)
infections, β-lactams are recommended for definitive therapy; however, the comparative …