Antibiotic resistance has increased markedly in gram-negative bacteria over the last two
decades, and in many cases has been associated with increased mortality and healthcare …

Antibiotic resistance among nosocomial pathogens in this country's hospitals adds
significantly to patient morbidity and mortality and the cost of health care. Optimism for …

Alexander Fleming's discovery of penicillin heralded an age of antibiotic development and
healthcare advances that are premised on the ability to prevent and treat bacterial infections …

PATHOGENS RESISTANT TO ANTIMICROBIAL AGENTS: Epidemiology, Molecular
Mechanisms, and Clinical Management - ScienceDirect Skip to main contentSkip to article …

Highlights•Carbapenem-resistant Gram-negative pathogens are a priority for R&D,
according to WHO.•Increasing need for new therapies against Klebsiella, Pseudomonas and …

Multidrug-resistant bacteria have on overwhelming impact on human health, as they cause
over 670,000 infections and 33,000 deaths annually in the European Union alone. Of these …

β-Lactam antibiotics are the cornerstone of our antibiotic armamentarium. By inhibiting
bacterial cell wall synthesis, they are highly effective against Gram-positive and Gram …

Antibiotics have been used to cure bacterial infections for more than 70 years, and these low-
molecular-weight bioactive agents have also been used for a variety of other medicinal …

Microbial drug resistance is an inescapable consequence of the utilization of antimicrobial
agents in a given environment. Nowhere is the importance of resistance more evident than …

Resistance to antimicrobial agents is emerging in a wide variety of nosocomial and
community-acquired pathogens. The emergence and spread of multiply resistant organisms …