This study investigated whether sacubitril/valsartan and ivabradine are able to prevent left
ventricular (LV) fibrotic remodelling and dysfunction in a rat experimental model of …

Angiotensin receptor blockers (ARBs) are often supplemented with calcium channel
blockers (CCBs) for treatment of hypertension. We recently showed that the L/N-type CCB …

Background: Sacubitril/Valsartan, a dual inhibitor of the neprilysin and angiotensin receptor,
exerts cardioprotective effects in heart failure. Little is known on the impact of …

Abstract Background Sacubitril/valsartan (S/V) has been shown to be an effective
antihypertensive drug combination. However, its therapeutic effects on blood pressure (BP) …

There is ample evidence on the benefit of angiotensin receptor-neprilysin inhibitors (ARNIs)
in heart failure, yet data regarding the potential protective action of ARNIs in hypertensive …

Treatment with an angiotensin blocker (ARB) and an aldosterone blocker has been shown
to have beneficial effects on cardiac remodeling in several cardiac diseases. It is still not …

Background Hypertensive left ventricular hypertrophy is associated with the risk of heart
failure, coronary heart disease and cerebrovascular disease. Although sacubitril/valsartan …

Background: We previously reported that a high-sodium diet activates the local renin-
angiotensin-aldosterone system (RAAS) in cardiovascular tissues of Dahl salt-sensitive …

This study was designed to investigate the effects of candesartan on blood pressure (BP)
and blood pressure variability (BPV) reductions, baroreflex sensitivity (BRS) amelioration …

Background: Sacubitril/valsartan was shown to attenuate the development of cardiac
hypertrophy with enhanced blood pressure reduction compared with valsartan alone in …