Effects of chronic high fat diet on mediobasal hypothalamic satiety neuron function in POMC-Cre mice

Ö Başer, Y Yavuz, DÖ Özen, HB Özgün, S Ağuş… - Molecular …, 2024 - Elsevier
Objective The prevalence of obesity has increased over the past three decades.
Proopiomelanocortin (POMC) neurons in the hypothalamic arcuate nucleus (ARC) play a …

[HTML][HTML] Hypothalamic Pomc expression restricted to GABAergic neurons suppresses Npy overexpression and restores food intake in obese mice

M Trotta, EP Bello, R Alsina, MB Tavella, JL Ferrán… - Molecular …, 2020 - Elsevier
Abstract Objective Hypothalamic arcuate proopiomelanocortin (Arc-POMC) neurons are
involved in different physiological processes such as the regulation of energy balance …

Temporal changes in nutritional state affect hypothalamic POMC peptide levels independently of leptin in adult male mice

AJ Mercer, RC Stuart, CA Attard… - American Journal …, 2014 - journals.physiology.org
Hypothalamic proopiomelanocortin (POMC) neurons constitute a critical anorexigenic node
in the central nervous system (CNS) for maintaining energy balance. These neurons directly …

Lean rats with hypothalamic pro-opiomelanocortin overexpression exhibit greater diet-induced obesity and impaired central melanocortin responsiveness

G Li, Y Zhang, KY Cheng, PJ Scarpace - Diabetologia, 2007 - Springer
Aims/hypothesis Central pro-opiomelanocortin (Pomc) gene therapy ameliorates genetic-or
age-related obesity. We hypothesised that this treatment would delay or prevent dietary …

GABA type B receptor signaling in proopiomelanocortin neurons protects against obesity, insulin resistance, and hypothalamic inflammation in male mice on a high-fat …

Y Ito, R Banno, M Shibata, K Adachi… - Journal of …, 2013 - Soc Neuroscience
There is evidence suggesting that the GABA system in the arcuate nucleus, where
orexigenic neuropeptide Y and agouti-related peptide as well as anorexigenic …

[HTML][HTML] Do POMC neurons have a sweet tooth for leptin? Special issue: Role of nutrients in nervous control of energy balance

N Srour, A Caron, NJ Michael - Biochimie, 2024 - Elsevier
Coordinated detection of changes in metabolic state by the nervous system is fundamental
for survival. Hypothalamic pro-opiomelanocortin (POMC) neurons play a critical role in …

[HTML][HTML] Sex difference in physical activity, energy expenditure and obesity driven by a subpopulation of hypothalamic POMC neurons

LK Burke, B Doslikova, G d'Agostino… - Molecular …, 2016 - Elsevier
Objective Obesity is one of the primary healthcare challenges of the 21st century. Signals
relaying information regarding energy needs are integrated within the brain to influence …

[PDF][PDF] POMC overexpression in the ventral tegmental area ameliorates dietary obesity

LM Andino, DJ Ryder, A Shapiro… - Journal of …, 2011 - researchgate.net
The activation of proopiomelanocortin (POMC) neurons in different regions of the brain,
including the arcuate nucleus of the hypothalamus (ARC) and the nucleus of the solitary …

Altered levels of POMC, AgRP and MC4-R mRNA expression in the hypothalamus and other parts of the limbic system of mice prone or resistant to chronic high …

XF Huang, M Han, T South, L Storlien - Brain research, 2003 - Elsevier
The melanocortinergic system plays an important role in promoting negative energy balance
and preventing excessive fat deposition. This study has investigated the levels of mRNA …

Simultaneous POMC gene transfer to hypothalamus and brainstem increases physical activity, lipolysis and reduces adult‐onset obesity

Y Zhang, E Rodrigues, G Li, Y Gao… - European Journal of …, 2011 - Wiley Online Library
Pro‐opiomelanocortin (POMC) neurons are identified in two brain sites, the arcuate nucleus
of the hypothalamus and nucleus of the solitary tract (NTS) in brainstem. Earlier …