[HTML][HTML] Wound microenvironment self-adaptive hydrogel with efficient angiogenesis for promoting diabetic wound healing

Z Shao, T Yin, J Jiang, Y He, T Xiang, S Zhou - Bioactive Materials, 2023 - Elsevier
Neovascularization is critical to improve the diabetic microenvironment, deliver abundant
nutrients to the wound and promote wound closure. However, the excess of oxidative stress …

A spatiotemporal release platform based on pH/ROS stimuli-responsive hydrogel in wound repairing

Y Wu, Y Wang, L Long, C Hu, Q Kong… - Journal of Controlled …, 2022 - Elsevier
Fabricating injectable hydrogel with multifunctions that matchs the highly ordered healing
process of skin regeneration has greatly desired in treatment of chronic diabetic wounds …

Development of a microenvironment-responsive hydrogel promoting chronically infected diabetic wound healing through sequential hemostatic, antibacterial, and …

C Guo, Y Wu, W Li, Y Wang, Q Kong - ACS Applied Materials & …, 2022 - ACS Publications
Microenvironment-responsive hydrogels present high potential in treating refractory wounds
due to their capability of on-demand drug release. In this study, a specially designed …

Biomimetic Nanozyme-Decorated Hydrogels with H2O2-Activated Oxygenation for Modulating Immune Microenvironment in Diabetic Wound

Y Zhao, D Wang, T Qian, J Zhang, Z Li, Q Gong… - ACS …, 2023 - ACS Publications
Diabetic foot ulcers (DFUs) remain a devastating threat to human health. While hydrogels
are promising systems for DFU-based wound management, their effectiveness is often …

Upregulating Hif‐1α by hydrogel nanofibrous scaffolds for rapidly recruiting angiogenesis relative cells in diabetic wound

H Chen, P Jia, H Kang, H Zhang, Y Liu… - Advanced …, 2016 - Wiley Online Library
Nonhealing chronic wounds on foot are one of the most dreaded complications of diabetes,
and biomedical scaffolds remain an attractive option for repairing or regenerating tissues …

Responsive multifunctional hydrogels emulating the chronic wounds healing cascade for skin repair

W Zhang, W Liu, L Long, S He, Z Wang, Y Liu… - Journal of Controlled …, 2023 - Elsevier
It remains challenging to cure chronic diabetic wounds due to its' harsh microenvironment
and poor tissue regeneration ability. At present, bacteria elimination, inflammatory response …

Microenvironment-responsive multifunctional hydrogels with spatiotemporal sequential release of tailored recombinant human collagen type III for the rapid repair of …

C Hu, W Liu, L Long, Z Wang, Y Yuan… - Journal of Materials …, 2021 - pubs.rsc.org
Recently, the incidence of chronic diabetic wounds increases continuously, and the existing
clinical treatment is less effective. Thus, it is an urgent need to solve these problems for …

Hyaluronic acid‐based reactive oxygen species‐responsive multifunctional injectable hydrogel platform accelerating diabetic wound healing

C Shi, Y Zhang, G Wu, Z Zhu, H Zheng… - Advanced …, 2024 - Wiley Online Library
Diabetic wounds are more likely to develop into complex and severe chronic wounds. The
objective of this study is to develop and assess a reactive oxygen species (ROS)‐responsive …

Quickly promoting angiogenesis by using a DFO-loaded photo-crosslinked gelatin hydrogel for diabetic skin regeneration

H Chen, L Guo, J Wicks, C Ling, X Zhao… - Journal of Materials …, 2016 - pubs.rsc.org
Changes in blood vessel formation, especially microvasculature formation, are one of the
most important factors contributing to the poor wound healing capabilities of diabetic …

Bioactive injectable hydrogels containing desferrioxamine and bioglass for diabetic wound healing

L Kong, Z Wu, H Zhao, H Cui, J Shen… - … applied materials & …, 2018 - ACS Publications
Diabetic wound is hard to heal mainly because of the difficulty in vascularization in the
wound area. Accumulating results have shown that desferrioxamine (DFO) can promote …