Novel treatments for autoimmune hepatitis (AIH) are highly demanded due to the limitations
of existing therapeutic agents. Costunolide is a promising candidate due to its anti …

Objective: This work aims to explore the potential targets and underlying therapeutic
mechanisms of celastrol in autoimmune hepatitis (AIH) through network pharmacology and …

The prevalence of autoimmune hepatitis (AIH) is increasing, yet specific pharmacotherapies
remain to be explored. The present study aimed to investigate the effects of sophoricoside …

Purpose Cholestatic liver diseases are groups of hepatobiliary diseases without curative
drug-based therapy options. Regulation of bile acid (BA) metabolism, hepatoperiductal …

Costunolide (cos) derived from the roots of Dolomiaea souliei (Franch.), which belongs to
the Dolomiaea genus in the family Compositae, exert the anti‐inebriation effect mainly by …

Ethnopharmacological relevance Sancao granule (SCG) is a traditional Chinese herb
formula, which has been used for autoimmune liver disease for decades. Previous study …

Costunolide, a sesquiterpene isolated from Vladimiria souliei (Franch.) Ling, is known to
exhibit anti-inflammatory, anti-viral, and anti-tumor activities. However, the effects of …

Objective: San-Cao granule (SCG), a traditional Chinese herb formula, has been used for
treating autoimmune hepatitis (AIH) in our clinics for a long time. However, its active …

Background Hepatic stellate cell (HSC) activation is a central event during hepatic fibrosis.
Aerobic glycolysis is one of its metabolic hallmarks. Blocking glycolysis is a novel …

Scoparone, a naturally-occurring, bioactive compound isolated from the Chinese herb
Artemisia capillaria, has been shown to ameliorate hepatotoxicity and cholestasis in liver …