Synthesis, antimicrobial evaluation, molecular docking and theoretical calculations of novel pyrazolo [1, 5-a] pyrimidine derivatives
New fused heterocyclic compounds were synthesized starting from dimethyl terephthalate,
as a versatile precursor, via its reactions with the appropriate reagents. The structures of the …
as a versatile precursor, via its reactions with the appropriate reagents. The structures of the …
Synthesis, biological evaluation and DFT calculation of novel pyrazole and pyrimidine derivatives
The utility of the enaminonitriles 3a and 3b for the synthesis of the pyrazole derivatives 5a, b,
7a, b, diaminopyrimidine derivatives 9, 11, pyrazolo [1, 5-a] pyrimidines 12, 15, triazolo [4, 3 …
7a, b, diaminopyrimidine derivatives 9, 11, pyrazolo [1, 5-a] pyrimidines 12, 15, triazolo [4, 3 …
New pyrazolo-triazolo-pyrimidine derivatives as antibacterial agents: Design and synthesis, molecular docking and DFT studies
M Horchani, A Hajlaoui, AH Harrath, L Mansour… - Journal of Molecular …, 2020 - Elsevier
A new series of antibacterial pyrazolo-triazolo-pyrimidine derivatives 3a-3i were synthesized
in two steps starting from aminopyrazole 1 and characterized by 1 H NMR 13 C NMR and …
in two steps starting from aminopyrazole 1 and characterized by 1 H NMR 13 C NMR and …
Pyrazolo-imidazolidinones: Synthesis, antimicrobial assessment and molecular modelling studies by molecular mechanic and quantum mechanic approach
Antimicrobial resistance (AMR) and multidrug resistance (MDR) have become global
therapeutic barriers and due to this, there is increasing global mortality. To overcome …
therapeutic barriers and due to this, there is increasing global mortality. To overcome …
Synthesis, molecular docking, and in silico ADME prediction of some fused pyrazolo[1,5-a]pyrimidine and pyrazole derivatives as potential antimicrobial agents
Abstract Twenty compounds of pyrazolo [1, 5-a] pyrimidines 14a–j and pyrazole derivatives
as Schiff bases 16a–j have been synthesized by the reaction of 5-amino-pyrazole …
as Schiff bases 16a–j have been synthesized by the reaction of 5-amino-pyrazole …
Synthesis of novel antipyrine-azole-S-alkyl derivatives antimicrobial activity, molecular docking, and computational studies
In this investigation, we synthesized the newly antipyrine-azole-S-alkyl and their reduction
derivatives that were screened for their antimicrobial activity and compared them with …
derivatives that were screened for their antimicrobial activity and compared them with …
Synthesis, antimicrobial and antiproliferative activities, molecular docking, and computational studies of novel heterocycles
AM Fahim, HEM Tolan, H Awad, EHI Ismael - Journal of the Iranian …, 2021 - Springer
We studied the reaction of enaminone 3 with some nitrogen nucleophiles to afford the
corresponding pyrazole 4, isoxazole 5, and pyrimidine 6 derivatives, and the reactivity of …
corresponding pyrazole 4, isoxazole 5, and pyrimidine 6 derivatives, and the reactivity of …
Efficient synthesis and molecular docking of novel antibacterial pyrimidines and their related fused heterocyclic derivatives
(Benzo [d][1, 3] dioxol‐5‐yl)‐1‐(thiophen‐2‐yl) prop‐2‐en‐1‐one reacted with each of
thiourea and 6‐amino‐2‐thioxo‐2, 3‐dihydropyrimidin‐4 (1H)‐one to give the …
thiourea and 6‐amino‐2‐thioxo‐2, 3‐dihydropyrimidin‐4 (1H)‐one to give the …
Synthesis, bioinformatics and biological evaluation of novel pyridine based on 8-hydroxyquinoline derivatives as antibacterial agents: DFT, molecular docking and …
The present study aims to first explore the relationship between the chemical structure of the
organic compounds (pyridine based on 8-hydroxyquinoline) and the antibacterial activities …
organic compounds (pyridine based on 8-hydroxyquinoline) and the antibacterial activities …
[HTML][HTML] Synthesis, characterization, and in vitro antibacterial activity of some new pyridinone and pyrazole derivatives with some in silico ADME and molecular …
KE Saadon, NMH Taha, NA Mahmoud… - Journal of the Iranian …, 2022 - Springer
A new series of pyridine-2-one and pyrazole derivatives were designed and synthesized
based on cyanoacrylamide derivatives containing 2, 4-dichlro aniline and 6-methyl 2-amino …
based on cyanoacrylamide derivatives containing 2, 4-dichlro aniline and 6-methyl 2-amino …