Daidzein reductase of Eggerthella sp. YY7918, its octameric subunit structure containing FMN/FAD/4Fe-4S, and its enantioselective production of R …
Y Kawada, T Goshima, R Sawamura… - Journal of bioscience …, 2018 - Elsevier
S-Equol is a metabolite of daidzein, a type of soy isoflavone, and three reductases are
involved in the conversion of daidzein by specific intestinal bacteria. S-Equol is thought to …
involved in the conversion of daidzein by specific intestinal bacteria. S-Equol is thought to …
Characterization and Identification of a New Daidzein Reductase Involved in (S)-Equol Biosynthesis in Clostridium sp. ZJ6
Y Hu, C Yang, C Song, W Zhong, B Li, L Cao… - Frontiers in …, 2022 - frontiersin.org
(S)-equol (EQ) is an isoflavone with high estrogen-like activity in the human body, and is
only produced by some gut bacteria in vivo. It plays an important role in maintaining …
only produced by some gut bacteria in vivo. It plays an important role in maintaining …
P212A Mutant of Dihydrodaidzein Reductase Enhances (S)-Equol Production and Enantioselectivity in a Recombinant Escherichia coli Whole-Cell Reaction System
ABSTRACT (S)-Equol, a gut bacterial isoflavone derivative, has drawn great attention
because of its potent use for relieving female postmenopausal symptoms and preventing …
because of its potent use for relieving female postmenopausal symptoms and preventing …
Cloning and expression of a novel NADP (H)-dependent daidzein reductase, an enzyme involved in the metabolism of daidzein, from equol-producing Lactococcus …
Y Shimada, S Yasuda, M Takahashi… - Applied and …, 2010 - Am Soc Microbiol
Equol is a metabolite produced from daidzein by enteric microflora, and it has attracted a
great deal of attention because of its protective or ameliorative ability against several sex …
great deal of attention because of its protective or ameliorative ability against several sex …
The production of S-equol from daidzein is associated with a cluster of three genes in Eggerthella sp. YY7918
Y Kawada, S Yokoyama, E Yanase, T Niwa… - … of microbiota, food …, 2016 - jstage.jst.go.jp
Daidzein (DZN) is converted to equol (EQL) by intestinal bacteria. We previously reported
that Eggerthella sp. YY7918, which is found in human feces, is an EQL-producing bacterium …
that Eggerthella sp. YY7918, which is found in human feces, is an EQL-producing bacterium …
Identification of a novel dihydrodaidzein racemase essential for biosynthesis of equol from daidzein in Lactococcus sp. strain 20-92
Y Shimada, M Takahashi, N Miyazawa… - Applied and …, 2012 - Am Soc Microbiol
Equol is metabolized from daidzein, a soy isoflavone, by the gut microflora. In this study, we
identified a novel dihydrodaidzein racemase (l-DDRC) that is involved in equol biosynthesis …
identified a novel dihydrodaidzein racemase (l-DDRC) that is involved in equol biosynthesis …
Exploring functional genes' correlation with (S)-equol concentration and new daidzein racemase identification
YF Hu, S Luo, SQ Wang, KX Chen… - Applied and …, 2024 - Am Soc Microbiol
With its estrogenic activity,(S)-equol plays an important role in maintaining host health and
preventing estrogen-related diseases. Exclusive production occurs through the …
preventing estrogen-related diseases. Exclusive production occurs through the …
Isoflavone daidzein: chemistry and bacterial metabolism
Isoflavone daidzein is a phytoestrogen widely distributed in Leguminosae and is especially
rich in the soybean. The C6-C3 (rings B and C) unit of isoflavones is derived from the …
rich in the soybean. The C6-C3 (rings B and C) unit of isoflavones is derived from the …
Biosynthesis of (−)-5-hydroxy-equol and 5-hydroxy-dehydroequol from soy isoflavone, genistein using microbial whole cell bioconversion
Equols are isoflavandiols formed by reduction of soy isoflavones such as daidzein and
genistein by gut microorganisms. These phytoestrogens are of interest for their various …
genistein by gut microorganisms. These phytoestrogens are of interest for their various …
Reduction of soy isoflavones by use of Escherichia coli whole‐cell biocatalyst expressing isoflavone reductase under aerobic conditions
YN Gao, QH Hao, HL Zhang, B Zhou… - Letters in Applied …, 2016 - academic.oup.com
Soy isoflavone metabolites are currently receiving much attention due to the stronger and
wider bioactivities than that of isoflavones. Therefore, biosynthesis of isoflavone metabolites …
wider bioactivities than that of isoflavones. Therefore, biosynthesis of isoflavone metabolites …