Voluntary exercise training is an effective way to prevent cardiovascular disease, since it
results in increased NO bioavailability and decreased reactive oxygen species (ROS) …

Objective—We investigated whether AMP-activated protein kinase (AMPK) may be involved
in the signaling processes leading to exercise-mediated vascular protection. Methods and …

Objective—Besides its well-described metabolic effects, vascular AMP-activated protein
kinase (AMPK) can activate endothelial NO synthase, promotes angiogenesis, and limits …

Mice with a global deletion of α1AMPK are characterized by endothelial dysfunction and
NADPH oxidase subunit 2 (NOX-2)-mediated vascular oxidative stress. However, the …

Exercise can prevent endothelial cell (EC) dysfunction and atherosclerosis even in the
absence of improvements in plasma lipids. However, the mechanisms responsible for these …

Chronic exercise training is known to protect the vasculature; however, the underlying
mechanisms remain obscure. The present study hypothesized that exercise may improve …

Endothelial dysfunction is caused by many factors, such as dyslipidemia, endoplasmic
reticulum (ER) stress, and inflammation. It has been demonstrated that endothelial …

Objective—AMP-activated protein kinase (AMPK), an energy and redox sensor, is activated
in response to various cellular stresses, including hypoxia, nutrient deprivation, oxidative …

Cardiovascular diseases represent the leading cause of global deaths and life years spent
with a severe disability. Endothelial dysfunction and vascular oxidative stress are early …

We investigated whether AMP‐activated protein kinase (AMPK), a multi‐functional regulator
of energy homeostasis, participates in the regulation of erythropoietin (EPO)‐mediated …