Anesthesiology Clin 35 (2017) e73–e94 http://dx. doi. org/10.1016/j. anclin. 2017.01. 012
anesthesiology. theclinics. com 1932-2275/17/© 2017 Elsevier Inc. All rights reserved …

BACKGROUND: Some drugs used for sedation and anesthesia produce histopathologic
central nervous system changes in juvenile animal models. These observations have raised …

Effective and safe drug administration in neonates should be based on integrated
knowledge on the evolving physiological characteristics of the infant who will receive the …

Developmental changes profoundly affect the clinical response to medicines. Dr. Abraham
Jacobi, a founder of American pediatrics, recognized more than a century ago that children …

BACKGROUND:: Historically, the use of anesthetics and analgesics in neonates and infants
has been based on extrapolations from studies performed in adults and older children. Over …

Abstract Anaesthesia dosing in infants (0–2 years) should be based on pharmacokinetic–
pharmacodynamic considerations and adverse effects profiles. Disease processes and …

The pediatric population is a very dynamic group of patients, since the physiologic
processes that determine drug disposition undergo rapid changes as children grow and …

Pharmacokinetic (PK) studies in neonates and young children have sometimes been
assumed less relevant than clinical studies for pediatric anesthetists; this, despite the earlier …

This review focuses on pharmacokinetics and pharmacodynamics of opioid and non-opioid
analgesics in neonates and infants. The unique physiology of this population differs from …

The shift in research from the neurotoxicity of anaesthetic agents to factors related to
anaesthetic conduct are discussed. Examples for an improvement in anaesthesia …