Male germ cells require multiple epigenetic reprogramming events during their lifespan to
achieve reproductive capacity. An emerging body of compelling data demonstrates that …

Spermatogenesis is a series of complex events involving a delicate balance between cell
proliferation and cell differentiation. Aggregation of chromatins and epigenetic modifications …

Male infertility is a widely debated issue that affects males globally. There are several
mechanisms involved. Oxidative stress is accepted to be the main contributing factor, with …

Infertility is a serious public health issue affecting around 15% of couples globally. Of the 60–
80 million people of reproductive age affected by infertility, 40–50% are due to male factor …

It has been suggested that during the past five decades human sperm counts have declined
and the incidence of testicular cancer, hypospadias and cryptorchidism has increased …

Disruptions to the genetic integrity of the mammalian spermatozoon play a major role in
determining the subsequent developmental trajectory of the embryo. This chapter examines …

Male reproductive health has been in decline for decades with dropping sperm counts and
increasing infertility, which has created a significant societal and economic burden. Between …

This review summarizes recent evidence that prenatal exposure to diverse environmental
chemicals dysregulates the fetal epigenome, with potential consequences for subsequent …

Over the past century, evidence has emerged that endocrine disrupting chemicals (EDCs)
have an impact on reproductive health. An increased frequency of reproductive disorders …

A variety of experimental and epidemiological studies lend support to the Developmental
Origin of Health and Disease (DOHaD) concept. Yet, the actual mechanisms accounting for …