[HTML][HTML] Angiogenesis-on-a-chip coupled with single-cell RNA sequencing reveals spatially differential activations of autophagy along angiogenic sprouts

S Lee, H Kim, BS Kim, S Chae, S Jung, JS Lee… - Nature …, 2024 - nature.com
Several functions of autophagy associated with proliferation, differentiation, and migration of
endothelial cells have been reported. Due to lack of models recapitulating angiogenic …

[HTML][HTML] Dynamic endothelial stalk cell–matrix interactions regulate angiogenic sprout diameter

WY Wang, EH Jarman, D Lin, BM Baker - Frontiers in Bioengineering …, 2021 - frontiersin.org
Angiogenesis is a complex, multicellular process that involves bidirectional interactions
between extracellular matrix (ECM) and collectively invading endothelial cell (EC) sprouts …

Biomimetic model to reconstitute angiogenic sprouting morphogenesis in vitro

DHT Nguyen, SC Stapleton, MT Yang… - Proceedings of the …, 2013 - National Acad Sciences
Angiogenesis is a complex morphogenetic process whereby endothelial cells from existing
vessels invade as multicellular sprouts to form new vessels. Here, we have engineered a …

[HTML][HTML] Autophagy protein 5 controls flow-dependent endothelial functions

P Nivoit, T Mathivet, J Wu, Y Salemkour… - Cellular and Molecular …, 2023 - Springer
Dysregulated autophagy is associated with cardiovascular and metabolic diseases, where
impaired flow-mediated endothelial cell responses promote cardiovascular risk. The …

Functional angiogenesis requires microenvironmental cues balancing endothelial cell migration and proliferation

WY Wang, D Lin, EH Jarman, WJ Polacheck… - Lab on a Chip, 2020 - pubs.rsc.org
Angiogenesis is a complex morphogenetic process that involves intimate interactions
between multicellular endothelial structures and their extracellular milieu. In vitro models of …

[HTML][HTML] VEGF triggers transient induction of autophagy in endothelial cells via AMPKα1

K Spengler, N Kryeziu, S Große, AS Mosig, R Heller - Cells, 2020 - mdpi.com
AMP-activated protein kinase (AMPK) is activated by vascular endothelial growth factor
(VEGF) in endothelial cells and it is significantly involved in VEGF-induced angiogenesis …

[HTML][HTML] Topography of extracellular matrix mediates vascular morphogenesis and migration speeds in angiogenesis

AL Bauer, TL Jackson, Y Jiang - PLoS computational biology, 2009 - journals.plos.org
The extracellular matrix plays a critical role in orchestrating the events necessary for wound
healing, muscle repair, morphogenesis, new blood vessel growth, and cancer invasion. In …

High‐throughput scaffold system for studying the effect of local geometry and topology on the development and orientation of sprouting blood vessels

AA Szklanny, L Debbi, U Merdler… - Advanced Functional …, 2020 - Wiley Online Library
Live tissues require vascular networks for cell nourishing. Mimicking the complex structure of
native vascular networks in vitro requires understanding the governing factors of early …

[HTML][HTML] Autophagy mediates paracrine regulation of vascular endothelial cells

K Woon Kim, P Paul, J Qiao, DH Chung - Laboratory investigation, 2013 - nature.com
Gastrin-releasing peptide (GRP) is a proangiogenic ligand secreted by tumors and acts
directly upon binding to GRP receptor in endothelial cells. Angiogenesis plays a critical role …

[HTML][HTML] Extracellular vesicles produced by human-induced pluripotent stem cell-derived endothelial cells can prevent arterial stenosis in mice via autophagy …

Y He, Q Li, F Feng, R Gao, H Li, Y Chu, S Li… - Frontiers in …, 2022 - frontiersin.org
Intravascular transplantation of human-induced pluripotent stem cells (hiPSCs)
demonstrated a significant therapeutic effect in the treatment of restenosis by the paracrine …