[HTML][HTML] Angiogenesis-on-a-chip coupled with single-cell RNA sequencing reveals spatially differential activations of autophagy along angiogenic sprouts
Several functions of autophagy associated with proliferation, differentiation, and migration of
endothelial cells have been reported. Due to lack of models recapitulating angiogenic …
endothelial cells have been reported. Due to lack of models recapitulating angiogenic …
[HTML][HTML] Dynamic endothelial stalk cell–matrix interactions regulate angiogenic sprout diameter
Angiogenesis is a complex, multicellular process that involves bidirectional interactions
between extracellular matrix (ECM) and collectively invading endothelial cell (EC) sprouts …
between extracellular matrix (ECM) and collectively invading endothelial cell (EC) sprouts …
Biomimetic model to reconstitute angiogenic sprouting morphogenesis in vitro
DHT Nguyen, SC Stapleton, MT Yang… - Proceedings of the …, 2013 - National Acad Sciences
Angiogenesis is a complex morphogenetic process whereby endothelial cells from existing
vessels invade as multicellular sprouts to form new vessels. Here, we have engineered a …
vessels invade as multicellular sprouts to form new vessels. Here, we have engineered a …
[HTML][HTML] Autophagy protein 5 controls flow-dependent endothelial functions
P Nivoit, T Mathivet, J Wu, Y Salemkour… - Cellular and Molecular …, 2023 - Springer
Dysregulated autophagy is associated with cardiovascular and metabolic diseases, where
impaired flow-mediated endothelial cell responses promote cardiovascular risk. The …
impaired flow-mediated endothelial cell responses promote cardiovascular risk. The …
Functional angiogenesis requires microenvironmental cues balancing endothelial cell migration and proliferation
Angiogenesis is a complex morphogenetic process that involves intimate interactions
between multicellular endothelial structures and their extracellular milieu. In vitro models of …
between multicellular endothelial structures and their extracellular milieu. In vitro models of …
[HTML][HTML] VEGF triggers transient induction of autophagy in endothelial cells via AMPKα1
AMP-activated protein kinase (AMPK) is activated by vascular endothelial growth factor
(VEGF) in endothelial cells and it is significantly involved in VEGF-induced angiogenesis …
(VEGF) in endothelial cells and it is significantly involved in VEGF-induced angiogenesis …
[HTML][HTML] Topography of extracellular matrix mediates vascular morphogenesis and migration speeds in angiogenesis
The extracellular matrix plays a critical role in orchestrating the events necessary for wound
healing, muscle repair, morphogenesis, new blood vessel growth, and cancer invasion. In …
healing, muscle repair, morphogenesis, new blood vessel growth, and cancer invasion. In …
High‐throughput scaffold system for studying the effect of local geometry and topology on the development and orientation of sprouting blood vessels
AA Szklanny, L Debbi, U Merdler… - Advanced Functional …, 2020 - Wiley Online Library
Live tissues require vascular networks for cell nourishing. Mimicking the complex structure of
native vascular networks in vitro requires understanding the governing factors of early …
native vascular networks in vitro requires understanding the governing factors of early …
[HTML][HTML] Autophagy mediates paracrine regulation of vascular endothelial cells
K Woon Kim, P Paul, J Qiao, DH Chung - Laboratory investigation, 2013 - nature.com
Gastrin-releasing peptide (GRP) is a proangiogenic ligand secreted by tumors and acts
directly upon binding to GRP receptor in endothelial cells. Angiogenesis plays a critical role …
directly upon binding to GRP receptor in endothelial cells. Angiogenesis plays a critical role …
[HTML][HTML] Extracellular vesicles produced by human-induced pluripotent stem cell-derived endothelial cells can prevent arterial stenosis in mice via autophagy …
Y He, Q Li, F Feng, R Gao, H Li, Y Chu, S Li… - Frontiers in …, 2022 - frontiersin.org
Intravascular transplantation of human-induced pluripotent stem cells (hiPSCs)
demonstrated a significant therapeutic effect in the treatment of restenosis by the paracrine …
demonstrated a significant therapeutic effect in the treatment of restenosis by the paracrine …