Background Oncology clinicians are now routinely provided with an estimated glomerular
filtration rate on pathology reports whenever serum creatinine is requested. The utility of …

Background. Glomerular filtration rate (GFR) is often used to determine initial dosing of
renally excreted cancer drugs. GFR can be calculated using the Cockcroft-Gault (CG) or the …

Background: Carboplatin is used in treating many types of cancer. Because renal excretion
is the major variable determining the pharmacokinetics of this drug, a dosing formula based …

Estimation of kidney function in patients with cancer directly affects drug dosing, agent
selection, and eligibility for clinical trials of novel agents. Overestimation of kidney function …

Background The aim of this study was to compare measured glomerular filtration rate (GFR)
with estimates of GFR derived from the population pharmacokinetic methods of Martin and …

Assessment of renal function prior to cisplatin chemotherapy has long been based on
measurement of creatinine clearance by 24-hour urine collection (Cr C meas). Estimated …

Monitoring renal function in patients with solid tumors and hematologic malignancies is vital
to the safe administration of therapeutic agents. Renal impairment is frequent in elderly …

MODERN THERAPEUTICS emphasizes regimen individ-ualization to maximize benefit
while minimizing adverse drug effects. Adjustment of a maintenance dose by interval …

Background: Serum creatinine (SCr)-based formulas are used to estimate glomerular
filtration rate (GFR) when calculating a dosage for carboplatin using the Calvert equation …

The frequent need to obtain an estimate of renal function in cancer patients, not least for
targeting carboplatin dose, has led to a number of approaches to estimate glomerular …