Background Accurate estimation of kidney function is essential for patient selection and drug
dosing in patients with cancer. eGFR equations are necessary for decision making and …

Background Seminoma stage I is the most frequent testis cancer and single-dose
carboplatin (AUC7) is an effective and widely used adjuvant treatment. Underdosing of …

Background: The aim of the study is to compare measured glomerular filtration rate by
technetium radiolabled diethylene tiamine pentaacetic acid (mGFR DTPA) to estimated GFR …

Background Traditionally, carboplatin dosage is based on the Calvert formula. Glomerular
filtration rate (GFR) and creatinine clearance (CrCl) are often used interchangeably in this …

Renal function-based carboplatin dosing is used routinely in paediatric oncology clinical
practice. It is important that accurate assessments of renal function are carried out …

Objective: Cisplatin-associated acute kidney injury is a common clinical event that causes
increased morbidity and mortality in cancer patients even if they are categorized as having …

Background Although a creatinine clearance (CrCl) of< 60 mL/min, as calculated by the
Cockroft-Gault (CG) equation, is a commonly used threshold for “cisplatin-ineligibility,” the …

The kidneys are the major excretory organs for many antitumor agents and their metabolites
and are therefore vulnerable to injury by the cytotoxic agents. Depending on the drugs …

Background: To evaluate cisplatin-induced nephrotoxicity in outpatients receiving
chemotherapy with cisplatin alone or in combination with other agents using a short …

Purpose While doses of carboplatin are mostly individualized according to the Calvert
equation based on estimated Glomerular Filtration Rate (eGFR), there is still uncertainty …